© 2002

Neuropilin: From Nervous System to Vascular and Tumor Biology

  • Dominique Bagnard

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 515)

Table of contents

  1. Front Matter
    Pages i-N8
  2. Anil Bagri, Marc Tessier-Lavigne
    Pages 13-31
  3. Michael Klagsbrun, Seiji Takashima, Roni Mamluk
    Pages 33-48
  4. Paul-Henri Romeo, Valérie Lemarchandel, Rafaele Tordjman
    Pages 49-54
  5. Fumio Nakamura, Yoshio Goshima
    Pages 55-69
  6. Andreas W. Püschel
    Pages 71-80
  7. V. Castellani
    Pages 91-102
  8. Joëlle Roche, Harry Drabkin, Elisabeth Brambilla
    Pages 103-114
  9. Fred De Winter, Anthony J. G. D. Holtmaat, Joost Verhaagen
    Pages 115-139
  10. Back Matter
    Pages 141-142

About this book


Cell adhesion is one of the most important properties controlling embryonic development. Extremely precise cell-cell contacts are established according to the nature of adhesion molecules that are expressed on the cell surface. The identifica­ tion of several families of adhesion molecules, well conserved throughout evolu­ tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs. Nowadays, cell adhesion molecules are not just considered as cellular glue but are thought to play critical roles in cell signaling. Their ability to influence cell proliferation, mi­ gration, or differentiation depends on both cell surface adhesion properties and acti­ vation of intracellular pathways. The next challenge will be to understand how these molecules interact with each other to ensure specific functions in the morphogen­ esis of very sophisticated systems. Indeed, by exploring the cellular and molecular mechanisms of nervous system development, the group of H. Fujisawa in Japan identified in 1987 an adhesion molecule, neuropilin, highly expressed in the neuro­ pile of amphibian optic tectum. Ten years later, two groups discovered that neuropilin is a receptor for guidance signals of the semaphorin family. Axon guidance is a critical step during brain development and the mechanisms ensuring growth cone navigation are beginning to be well understood. The semaphorins are bifunctional signals defining permissive or inhibitory pathways sensed by the growth cone.


Herz Nervous System Tumor angiogenesis behavior biology

Editors and affiliations

  • Dominique Bagnard
    • 1
  1. 1.Maître de ConférencesUniversité Louis PasteurStrasbourgFrance

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