Molecular Determinants of Head and Neck Cancer

  • Barbara Burtness
  • Erica A. Golemis

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Barbara Burtness, Erica A. Golemis
    Pages 1-5
  3. Hanqing Liu, Jennifer R. Cracchiolo, Tim N. Beck, Ilya G. Serebriiskii, Erica A. Golemis
    Pages 55-90
  4. Tanguy Y. Seiwert, Tim N. Beck, Ravi Salgia
    Pages 91-111
  5. Steven A. Rosenzweig, Casey O. Holmes
    Pages 113-130
  6. Jason D. Howard, Christine H. Chung
    Pages 131-161
  7. Bhavana S. Vangara, Jennifer R. Grandis
    Pages 163-177
  8. Jill M. Neiman, Xiao-Jing Wang
    Pages 179-197
  9. Rogerio M. Castilho, J. Silvio Gutkind
    Pages 199-214
  10. Jong-Lyel Roh, Wayne M. Koch
    Pages 227-258
  11. Ranee Mehra, Ilya G. Serebriiskii
    Pages 259-282
  12. Peiwen Kuo, Quynh-Thu Le
    Pages 283-302
  13. Curtis R. Pickering, Thomas J. Ow, Jeffrey N. Myers
    Pages 303-323
  14. Michael F. Ochs, Joseph A. Califano
    Pages 325-341
  15. Back Matter
    Pages 361-362

About this book

Introduction

Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity. As this book addresses this difficult disease, it accomplishes three main goals.

First, it introduces the etiology and subclasses of squamous cell carcinomas of the head and neck (SCCHNs), and how these factors affect prognosis. Although habitual exposures to tobacco, alcohol, and other agents have historically been the main causes of SCCHN, a rising proportion of oropharynx cancers arise from transforming human papillomavirus (HPV) infection. These two broad classes of SCCHN have significant differences in disease profile and response to treatment, as we discuss.

Second, it summarizes the current state of understanding of the genetic, epigenetic and protein expression changes associated with the various classes of SCCHN. In the past decade, disease pathogenesis of SCCHN has been appreciated to involve deregulation of multiple tumor pathways, including the receptor tyrosine kinases (RTKs) EGFR, ERBB2, ERBB3, c-MET, and IGF1R; transforming growth factor β (TGFβ); Notch; cytoplasmic signaling proteins including PTEN, PI3K, JAK/STAT, and Wnt-responsive β-catenin; mutation control systems, including p53 and the DNA damage repair (DDR) machinery; and hypoxic response. The specific understanding of the action of these proteins in SCCHN is presented here.

Finally, this book defines potential therapeutic targets for improved management of the disease in the future, discussing prospects for improved prediction of prognosis.

Keywords

Dna repair Human Papillomavirus genomics head and neck cancer hypoxia molecular determinants

Editors and affiliations

  • Barbara Burtness
    • 1
  • Erica A. Golemis
    • 2
  1. 1.Developmental Therapeutics ProgramFox Chase Cancer CenterPhiladelphiaUSA
  2. 2.Developmental Therapeutics ProgramFox Chase Cancer CenterPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-8815-6
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-8814-9
  • Online ISBN 978-1-4614-8815-6
  • About this book
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