Oocyte Biology in Fertility Preservation

  • S. Samuel Kim

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 761)

Table of contents

  1. Front Matter
    Pages i-x
  2. Meltem Kurus, Cengiz Karakaya, Mete Hakan Karalok, Grace To, Joshua Johnson
    Pages 7-18
  3. David F. Albertini, Rachel Olsen
    Pages 19-27
  4. Jing Xu, Min Xu, Marcelo P. Bernuci, Thomas E. Fisher, Lonnie D. Shea, Teresa K. Woodruff et al.
    Pages 43-67
  5. Roger G. Gosden
    Pages 85-94
  6. Back Matter
    Pages 95-97

About this book

Introduction

​Fertility preservation has become one of the most important and fast growing fields of reproductive medicine.  Although there are several strategies for fertility preservation in female, most of them are still considered experimental.  It is important to perfect the existing technologies, but also developing new strategies should be actively sought.  The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles.  One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms.  To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level.  Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation.  The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.​ 

Keywords

Epigenetics Fertility Preservation Follicle Development Oocytes Ovarian Biology Reproductive Techonologies

Editors and affiliations

  • S. Samuel Kim
    • 1
  1. 1.University of Kansas Medical CenterKansas CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-8214-7
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-8213-0
  • Online ISBN 978-1-4614-8214-7
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • About this book
Industry Sectors
Biotechnology
Pharma