Epigenetics and Complex Traits

  • Anna K. Naumova
  • Celia M.T. Greenwood

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Epigenetic Phenomena in the Germ Line and Early Embryonic Development and Their Effects on the Inheritance of Genetic Traits

    1. Front Matter
      Pages 1-1
    2. Stéphanie Maupetit-Méhouas, David Nury, Philippe Arnaud
      Pages 3-34
    3. Wendy P. Robinson, Allison M. Cotton, Maria S. Peñaherrera, Samantha B. Peeters, Carolyn J. Brown
      Pages 63-88
    4. Michel Georges, Haruko Takeda, Huijun Cheng, Xu Xuewen, Tracy Hadfield-Shay, Noelle Cockett et al.
      Pages 89-106
    5. Virginia Savova, Alexander A. Gimelbrant
      Pages 131-144
  3. Epigenetic Variation in Health and Disease

    1. Front Matter
      Pages 145-145
    2. Janine M. LaSalle, Mohammad Saharul Islam
      Pages 147-178
    3. Amanda Ewart Toland
      Pages 209-229
  4. Impact of Epigenetics on Complex Trait Genetics and Analysis

    1. Front Matter
      Pages 231-231
    2. Robert E. Furrow, Freddy B. Christiansen, Marcus W. Feldman
      Pages 233-246
    3. Janet S. Sinsheimer, Michelle M. Creek
      Pages 247-264
  5. Back Matter
    Pages 339-341

About this book

Introduction

Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits.

 

Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance.

 

Epigenetics and Complex Traits is a  resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance. 

                                    

Keywords

complex traits molecular genetics population genetics

Editors and affiliations

  • Anna K. Naumova
    • 1
  • Celia M.T. Greenwood
    • 2
  1. 1.Departments of Obstetrics and Gynecology and Human GeneticsMcGill UniversityMontrealCanada
  2. 2.Lady Davis Institute for Medical Research Centre for Clinical EpidemiologyJewish General HospitalMontrealCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-8078-5
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-8077-8
  • Online ISBN 978-1-4614-8078-5
  • About this book
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