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Systems Analysis of Chromatin-Related Protein Complexes in Cancer

  • Andrew Emili
  • Jack Greenblatt
  • Shoshana Wodak

Table of contents

  1. Front Matter
    Pages i-xi
  2. Edyta Marcon, Sandra Smiley, Andrei L. Turinsky, Jack Greenblatt
    Pages 1-32
  3. Jonathan B. Olsen, Jack Greenblatt, Andrew Emili
    Pages 33-47
  4. Shuye Pu, Andrei L. Turinsky, Shoshana Wodak
    Pages 49-63
  5. Dorothy Yanling Zhao, Yue Li, Jack Greenblatt, Zhaolei Zhang
    Pages 87-115
  6. Alain Doucet, Daniel Figeys
    Pages 117-131
  7. Natarajan V. Bhanu, Benjamin A. Garcia
    Pages 149-175
  8. Mahadevan Lakshminarasimhan, Michael P. Washburn
    Pages 177-196
  9. Victoria M. Richon, Mikel P. Moyer, Robert A. Copeland
    Pages 239-256
  10. Harry Yu Zhou, Jennifer A. Mitchell
    Pages 257-276
  11. Mina Rafiei, Rod Bremner
    Pages 277-296
  12. Troy Ketela, Kevin R. Brown, Jason Moffat
    Pages 297-308
  13. Back Matter
    Pages 309-316

About this book

Introduction

Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research.

Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized.

To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery.

What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

Keywords

DNA methylation chromatin structure histone chaperones histone demethylases proteomics somatic mutations

Editors and affiliations

  • Andrew Emili
    • 1
  • Jack Greenblatt
    • 2
  • Shoshana Wodak
    • 3
  1. 1.Banting & Best Dept. Medical ResearchUniversity of Toronto Donnelly Ctr Cell. & Biomolecular Res.TorontoCanada
  2. 2.University of Toronto Terrence Donnelly Centre for Cellular and Biomolecular ResearchTorontoCanada
  3. 3.Molecular Structure and Function ProgramThe Hospital for Sick ChildrenTorontoCanada

Bibliographic information

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