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Cancer Targeted Drug Delivery

An Elusive Dream

  • You Han Bae
  • Randall J. Mrsny
  • Kinam Park

Table of contents

  1. Front Matter
    Pages i-xvii
  2. History of Cancer Targeting Efforts

    1. Front Matter
      Pages 1-1
    2. Ana S. Cravo, Randall J. Mrsny
      Pages 3-35
    3. Joseph W. Nichols, You Han Bae
      Pages 37-56
  3. Targeting Issues

    1. Front Matter
      Pages 57-57
    2. Joseph W. Wragg, Roy Bicknell
      Pages 59-95
    3. Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba
      Pages 97-118
  4. General Tumor Physiology and Microenvironment Issues

    1. Front Matter
      Pages 119-119
    2. Abood Okal, Shams Reaz, Carol S. Lim
      Pages 121-159
    3. Dong Yun Lee, Taiyoun Rhim, Minhyung Lee
      Pages 183-206
    4. Sebastien Taurin, Hayley Nehoff, Thalita van Aswegen, Khaled Greish
      Pages 207-239
    5. Shawn Stapleton, Michael F. Milosevic
      Pages 241-272
    6. M. J. Duffy, M. Mullooly, J. Crown, P. M. McGowan
      Pages 273-287
  5. The Dynamic Problem of Tumor Heterogeneity

    1. Front Matter
      Pages 335-335
    2. Min Han, Jian-Qing Gao
      Pages 389-412
    3. Dejuan Kong, Yiwei Li, Aamir Ahmad, Bin Bao, Asfar Azmi, Fazlul H. Sarkar
      Pages 413-433
    4. Ngoc-Han Ha, Farhoud Faraji, Kent W. Hunter
      Pages 435-458
  6. Reaching Cancer Cells

    1. Front Matter
      Pages 459-459
    2. Ewelina Kluza, Gustav J. Strijkers, Regina G. H. Beets-Tan, Klaas Nicolay
      Pages 461-507
    3. Shiran Ferber, Galia Tiram, Ronit Satchi-Fainaro
      Pages 509-542
    4. Sandra N. Ekdawi, Andrew S. Mikhail, Shawn Stapleton, Jinzi Zheng, Sina Eetezadi, David A. Jaffray et al.
      Pages 543-571
    5. Abraham R. Tzafriri, Elazer R. Edelman
      Pages 573-606
    6. Yu Matsumoto, Takahiro Nomoto, Kazuko Toh, Horacio Cabral, Mami Murakami, R. James Christie et al.
      Pages 607-620
    7. Ji Young Yhee, Sejin Son, Sohee Son, Min Kyung Joo, Ick Chan Kwon
      Pages 621-632
  7. Preclinical Modeling

    1. Front Matter
      Pages 633-633
    2. Waseem Asghar, Hadi Shafiee, Pu Chen, Savas Tasoglu, Sinan Guven, Umut Atakan Gurkan et al.
      Pages 635-665
  8. Prospective and Future Direction

    1. Front Matter
      Pages 687-687
    2. Kinam Park, You Han Bae, Randall J. Mrsny
      Pages 689-707
  9. Back Matter
    Pages 709-720

About this book

Introduction

This book was conceived from a simple question as to why cancer is so difficult to treat.  Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future.  This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors.  This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications.  The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications.  The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications.  Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Keywords

Cancer Cancer cells Cancer tharapy Drug delivery Tumor Tumor heterogeneity

Editors and affiliations

  • You Han Bae
    • 1
  • Randall J. Mrsny
    • 2
  • Kinam Park
    • 3
  1. 1.Pharmacutics & Pharmacutical ChemistryUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Pharmacy & PharmacologyUniversity of BathClaverton Down, BathUnited Kingdom
  3. 3.Department of Biomedical EngineeringPurdue UniversityWest LafayetteUSA

Bibliographic information

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