© 2014

Tumor Microenvironment and Cellular Stress

Signaling, Metabolism, Imaging, and Therapeutic Targets

  • Constantinos Koumenis
  • Ester Hammond
  • Amato Giaccia
  • Explores significant advances in understanding the genetic determinants of stress responses?

  • Discusses various cellular and animal models of tumor microenvironment study

  • Features novel targets for imaging and therapeutic intervention

Conference proceedings

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 772)

Table of contents

  1. Front Matter
    Pages i-x
  2. Karim Bensaad, Adrian L. Harris
    Pages 1-39
  3. Zhong Yun, Qun Lin
    Pages 41-53
  4. Joan Chang, Janine Erler
    Pages 55-81
  5. Lee Rivera, Melissa Pandika, Gabriele Bergers
    Pages 83-99
  6. M. Christiane Brahimi-Horn, N. M. Mazure
    Pages 101-110
  7. Michael P. Hay, Kevin O. Hicks, Jingli Wang
    Pages 111-145
  8. Mircea Ivan, Xin Huang
    Pages 205-227
  9. Ruben Pio, Leticia Corrales, John D. Lambris
    Pages 229-262
  10. Back Matter
    Pages 285-290

About these proceedings


The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.


drug discovery hypoxia microenvironment therapy tumor

Editors and affiliations

  • Constantinos Koumenis
    • 1
  • Ester Hammond
    • 2
  • Amato Giaccia
    • 3
  1. 1.Department of Radiation OncologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaUSA
  2. 2.Cancer ResearchGray Institute for Radiation OncologyOxfordUnited Kingdom
  3. 3.Department of Radiation OncologyStanford University School of MedicineStanfordUSA

About the editors

Constantinos Koumenis, Ph.D. is an Associate Professor, Vice Chair and Research Division Director and Co-Leader, Radiation Biology & Imaging Program at the University of Pennsylvania, School of Medicine. Amato Giacca,Ph.D., is a Professor and Director of the Department of Radiation Oncology, Leader of Radation Biology and Molecular Therapeutics Program at the Stanford Cancer Center. Ester Hammond Ph.D., is a Junior Group Leader at Gray Institute for Radiation Oncology and Biology at Oxford University.

Bibliographic information

  • Book Title Tumor Microenvironment and Cellular Stress
  • Book Subtitle Signaling, Metabolism, Imaging, and Therapeutic Targets
  • Editors Constantinos Koumenis
    Ester Hammond
    Amato Giaccia
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-5914-9
  • Softcover ISBN 978-1-4939-4705-8
  • eBook ISBN 978-1-4614-5915-6
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages X, 290
  • Number of Illustrations 8 b/w illustrations, 30 illustrations in colour
  • Topics Cancer Research
    Human Physiology
    Medical Microbiology
  • Buy this book on publisher's site
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