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Tandem Repeat Polymorphisms

Genetic Plasticity, Neural Diversity and Disease

  • Book
  • © 2012

Overview

Editors:
  1. Anthony J. Hannan

    1. Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne, Parkville, Australia

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  • Focuses on key aspects of TRPs in health and disease
  • Provides a detailed discussion of repeat sequences as mutable sites providing genetic variability upon which natural selection can act
  • Provides insights into how expanded polyalanine in specific proteins leads to developmental abnormalities and neurocognitive dysfunction

Part of the book series: Advances in Experimental Medicine and Biology (AEMB)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xix
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  2. Tandem Repeat Polymorphisms

    • Anthony J. Hannan
    Pages 1-9

  3. Evolution of Simple Sequence Repeats as Mutable Sites

    • David G. King
    Pages 10-25

  4. Single Amino Acid and Trinucleotide Repeats

    • Noel Faux
    Pages 26-40

  5. Promoter Microsatellites as Modulators of Human Gene Expression

    • Sterling M. Sawaya, Andrew T. Bagshaw, Emmanuel Buschiazzo, Neil J. Gemmell
    Pages 41-54

  6. Dynamic Mutations

    • Clare L. van Eyk, Robert I. Richards
    Pages 55-77

  7. Unstable Mutations in the FMR1 Gene and the Phenotypes

    • Danuta Loesch, Randi Hagerman
    Pages 78-114

  8. Molecular Pathways to Polyglutamine Aggregation

    • Amy L. Robertson, Stephen P. Bottomley
    Pages 115-124

  9. Polyglutamine Aggregation in Huntington and Related Diseases

    • Saskia Polling, Andrew F. Hill, Danny M. Hatters
    Pages 125-140

  10. Selective Neurodegeneration, Neuropathology and Symptom Profiles in Huntington’s Disease

    • Henry J. Waldvogel, Doris Thu, Virginia Hogg, Lynette Tippett, Richard L. M. Faull
    Pages 141-152

  11. Kennedy’s Disease

    • Jeffrey D. Zajac, Mark Ng Tang Fui
    Pages 153-168

  12. Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia

    • Louise A. Corben, Nellie Georgiou-Karistianis, John L. Bradshaw, Marguerite V. Evans-Galea, Andrew J. Churchyard, Martin B. Delatycki
    Pages 169-184

  13. Polyalanine Tract Disorders and Neurocognitive Phenotypes

    • Cheryl Shoubridge, Jozef Gecz
    Pages 185-203

  14. Back Matter

    Pages 205-208
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Keywords

About this book

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

Editors and Affiliations

  • Florey Neuroscience Institutes, Melbourne Brain Centre, University of Melbourne, Parkville, Australia

    Anthony J. Hannan

About the editor

ANTHO NY J. HANNAN is Head of the Neural Plasticity Laboratory, Florey Neuroscience Institutes and Associate Professor at the University of Melbourne, Parkville, Australia. Following undergraduate and PhD degrees at the University of Sydney, Anthony received postdoctoral neuroscience training at the University of Oxford, supported by a Nuffield Medical Fellowship. He currently holds an Australian Research Council (ARC) Future Fellowship (FT3) and an Honorary Senior Research Fellowship from the National Health and Medical Research Council (NHMRC). Main research interests include pathogenic mechanisms mediating Huntington’s disease and related tandem repeat expansion disorders, as well as other cognitive and psychiatric illnesses. In his laboratory, experimental models of gene‑environment interactions are used to explore experience‑dependent plasticity in the healthy and diseased brain.

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