Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

  • Manmohan Singh

Table of contents

  1. Front Matter
    Pages i-x
  2. Novel Immune Potentiators and Delivery Systems for Enhancing Vaccine Potency

    1. Front Matter
      Pages 1-1
    2. Mark A. Tomai, John P. Vasilakos
      Pages 3-18
    3. Josianne Nitcheu, Sandrine Crabe, Gwyn Davies, Vincent Serra
      Pages 19-64
    4. Olga Borges, Gerrit Borchard
      Pages 65-80
    5. Wendy Peters, Ciaran D. Scallan, Sean N. Tucker
      Pages 81-104
  3. Design and Development of Next Generation Vaccines

    1. Front Matter
      Pages 105-105
    2. C. Russell Middaugh, David B. Volkin, Sangeeta B. Joshi
      Pages 119-143
  4. Novel Delivery Technologies for Vaccines

  5. Novel Particulate Delivery Systems for Vaccines and Adjuvants

    1. Front Matter
      Pages 267-267
    2. Tarek Hamouda, Jakub Simon, Ali Fattom, James Baker
      Pages 269-286
    3. Christian Moser, Mario Amacker
      Pages 287-307
    4. Karin Lövgren Bengtsson
      Pages 309-320
  6. Safety Assessment of Next Generation Vaccines

    1. Front Matter
      Pages 321-321
    2. Jayanthi J. Wolf, Lisa M. Plitnick, Danuta J. Herzyk
      Pages 323-349
    3. S. Sohail Ahmed, Ernesto Oviedo-Orta, Jeffrey Ulmer
      Pages 351-364
  7. Back Matter
    Pages 365-369

About this book


Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​


Adjuvants Immunity Vaccines

Editors and affiliations

  • Manmohan Singh
    • 1
  1. 1.Novartis Vaccines ResearchCambridgeUSA

Bibliographic information

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