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RNA Interference from Biology to Therapeutics

  • Book
  • © 2013

Overview

Editors:
  1. Kenneth A. Howard

    1. Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark

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  • Addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches
  • Covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects
  • Discusses current delivery technologies to overcome both intracellular and extracellular barriers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. RNA Interference Pathways and Therapeutic Exploitation

    • Jesper B. Bramsen, Thomas B. Hansen
    Pages 1-29

  3. Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference

    • Scott D. Rose, Mark A. Behlke
    Pages 31-56

  4. The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

    • Morten Østergaard Andersen, Philipp Dillschneider, Jørgen Kjems
    Pages 57-78

  5. Intracellular Delivery Considerations for RNAi Therapeutics

    • Yu Zhu, Jing Li, David Oupický
    Pages 79-95

  6. Mucosal Delivery of RNAi Therapeutics

    • Borja Ballarín González, Ebbe Bech Nielsen, Troels Bo Thomsen, Kenneth A. Howard
    Pages 97-125

  7. Nanomedicines for Systemic Delivery of RNAi Therapeutics

    • Dan Peer
    Pages 127-142

  8. Lipidoids: A Combinatorial Approach to siRNA Delivery

    • Michael Goldberg
    Pages 143-160

  9. Polymeric Micelles for siRNA Delivery

    • Frederico Pittella, Kazunori Kataoka
    Pages 161-184

  10. RNAi Therapeutic Delivery by Exosomes

    • Samira Lakhal, Samir El Andaloussi, Aisling J. O’Loughlin, Jinghuan Li, Matthew M. J. Wood
    Pages 185-205

  11. Aptamer-Mediated siRNA Targeting

    • Jiehua Zhou, John J. Rossi
    Pages 207-220

  12. RNAi as Antiviral Therapy: The HIV-1 Case

    • Ben Berkhout, Julia J. M. Eekels
    Pages 221-242

  13. Genome-Wide RNAi Screening to Identify Human Host Factors Crucial for Influenza Virus Replication

    • Katharina Ahrens, Alexander Karlas
    Pages 243-257

  14. The Application of MicroRNAs in Cancer Diagnostics

    • Karina D. Sørensen, Marie S. Ostenfeld, Dennis K. Jeppesen, Helle Kristensen, Christa Haldrup, Torben F. Ørntoft
    Pages 259-298

  15. Therapeutic Application of MicroRNAs in Cancer

    • Nobuyoshi Kosaka, Fumitaka Takeshita, Yusuke Yoshioka, Takahiro Ochiya
    Pages 299-314

  16. Preclinical and Clinical Studies Employing RNA Interference as a Therapeutic for Respiratory Syncytial Virus (RSV) Infection in the Lung

    • Amy R. Simon, Verena Karsten, Rachel Meyers, Jeff Cehelsky, Jared Gollob, Akshay Vaishnaw et al.
    Pages 315-328

  17. Back Matter

    Pages 329-337
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Keywords

About this book

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.

Editors and Affiliations

  • Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark

    Kenneth A. Howard

About the editor

Kenneth Alan Howard is an Associate Professor and Group Leader at the Department of Molecular Biology at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark. His team is based in a highly interdisciplinary setting with research and teaching activities focused on advanced drug delivery, nanomedicine, RNA interference, and inflammation. Dr Howard is CEO of an Aarhus University spin-out company that provides delivery solutions for RNA interference-based therapeutics. Kenneth Alan Howard received a PhD in Pharmaceutical Science from the University of Nottingham, UK in 1995, and has held postdoctoral positions at the CRC Institute for Cancer Studies, University of Birmingham, UK and the School of Pharmacy, University of London. Dr Howard is an active member of the Controlled Release Society serving on the Board of Scientific Advisors (chair), Nominations Committee and organizer of a CRS Educational workshop “RNA Interference Biology and Therapeutics”.   

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