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Genetic and Molecular Epidemiology of Multiple Myeloma

  • Book
  • © 2013

Overview

Editors:
  1. Suzanne Lentzsch

    1. College of Physicians and Surgeons, Multiple Myeloma and Amyloidosis Service, Columbia University, New York, USA

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  • Explores the role of protein translation in multiple myeloma

  • Discusses epigenetic gene silencing as a new target for multiple myeloma immune surveillance

  • Examines the cell cycle control of plasma cell differentiation

  • Includes supplementary material: sn.pub/extras

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-vii
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  2. Genetics of Multiple Myeloma

    • Steven Schuster, Esteban Braggio, Rafael Fonseca
    Pages 1-16

  3. Gene Expression Signature in MGUS and Multiple Myeloma

    • Christoph J. Heuck, Sarah K. Johnson, Qing Zhang, John D. Shaughnessy Jr.
    Pages 17-41

  4. Cap-Dependent Protein Translation Initiation in Multiple Myeloma: An Attractive Target for Therapy

    • Shirong Li, Jing Fu, Suzanne Lentzsch
    Pages 43-57

  5. IRES-Dependent, Cap-Independent Translation in Multiple Myeloma

    • Joseph Gera, Alan Lichtenstein
    Pages 59-76

  6. The Role of Notch Signaling in Multiple Myeloma

    • Dehui Xu, Jinsong Hu, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Els Van Valckenborgh
    Pages 77-95

  7. Role of Bone Disease in the Pathogenesis of Multiple Myeloma

    • G. David Roodman
    Pages 97-120

  8. Back Matter

    Pages 121-125
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Keywords

About this book

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma. This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.

Editors and Affiliations

  • College of Physicians and Surgeons, Multiple Myeloma and Amyloidosis Service, Columbia University, New York, USA

    Suzanne Lentzsch

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