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Antibiotic Discovery and Development

  • Thomas J. Dougherty
  • Michael J. Pucci

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introductory History of Antimicrobial Drugs

  3. Marketed Major Classes of Compounds

    1. Front Matter
      Pages 77-77
    2. Malcolm G. P. Page
      Pages 79-117
    3. George A. Jacoby, David C. Hooper
      Pages 119-146
    4. Patricia A. Bradford, C. Hal Jones
      Pages 147-179
    5. Ze-Qi Xu, Michael T. Flavin, David A. Eiznhamer
      Pages 181-228
    6. Eliana S. Armstrong, Corwin F. Kostrub, Robert T. Cass, Heinz E. Moser, Alisa W. Serio, George H. Miller
      Pages 229-269
    7. Michael R. Barbachyn
      Pages 271-299
    8. F. F. Arhin, A. Belley, A. Rafai Far, D. Lehoux, G. Moeck, T. R. Parr Jr.
      Pages 301-346
  4. The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes

    1. Front Matter
      Pages 347-347
    2. Keith Poole
      Pages 349-395
    3. Sai Lakshmi Subramanian, Haripriya Ramu, Alexander S. Mankin
      Pages 455-484
    4. Karl Drlica, Xilin Zhao, Muhammad Malik, Tal Salz, Robert Kerns
      Pages 485-514
    5. Bruno Périchon, Patrice Courvalin
      Pages 515-542
    6. Marilyn C. Roberts
      Pages 543-568
  5. Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes Gram-positives

    1. Front Matter
      Pages 569-569
    2. Duarte C. Oliveira, Hermínia de Lencastre, Alexander Tomasz
      Pages 571-592
    3. German A. Contreras, Cesar A. Arias
      Pages 617-648
  6. Gram-negatives

    1. Front Matter
      Pages 649-649
    2. David F. Briceño, Julián A. Torres, José D. Tafur, John P. Quinn, María V. Villegas
      Pages 651-678
    3. Kristen N. Schurek, Elena B. M. Breidenstein, Robert E. W. Hancock
      Pages 679-715
  7. Mycobacteria

  8. Antibiotic Discovery

    1. Front Matter
      Pages 751-751
    2. Sheo B. Singh
      Pages 821-847
    3. Wright W. Nichols
      Pages 849-879
    4. Sarah M. McLeod, Thomas J. Dougherty, Michael J. Pucci
      Pages 881-900
    5. Scott D. Mills, Thomas J. Dougherty
      Pages 901-929
    6. David E. Ehmann, Stewart L. Fisher
      Pages 931-956
    7. Lloyd G. Czaplewski, Neil R. Stokes, Steve Ruston, David J. Haydon
      Pages 957-968
    8. Jun Hu, Gunther Kern
      Pages 985-1007
    9. Jared L. Crandon, David P. Nicolau
      Pages 1035-1054
  9. Antibiotic Drug Development

    1. Front Matter
      Pages 1069-1069
    2. Jane E. Ambler, Greg G. Stone
      Pages 1071-1100
  10. The Economics and Incentives of Antibiotic Drug Discovery

    1. Front Matter
      Pages 1101-1101
  11. Back Matter
    Pages 1107-1127

About this book

Introduction

This volume covers major aspects of the antibiotic discovery and development process. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the historical perspectives of antibiotic discovery, the need for new antibiotic compounds,strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Significant attention is given to existing antibiotics, their resistance mechanisms, and new efforts to overcome resistance within these classes.  Beyond discovery, the book covers the studies to prepare for IND submission and NDA filings. This book walks the reader through virtually all aspects of antibiotic discovery, which has never been done before in a single reference.

With the alarming rise in antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the book is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Editors and affiliations

  • Thomas J. Dougherty
    • 1
  • Michael J. Pucci
    • 2
  1. 1., Senior Principal ScientistAstraZeneca Pharmaceuticals LPWalthamUSA
  2. 2.Achillion Pharmaceuticals, Inc.New HavenUSA

Bibliographic information

Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods