Tumour-Associated Macrophages

  • Toby Lawrence
  • Thorsten Hagemann

Table of contents

  1. Front Matter
    Pages i-xi
  2. Form and Function

    1. Front Matter
      Pages 1-1
    2. Hsi-Hsien Lin, Siamon Gordon
      Pages 3-16
    3. Russell Hughes, Hsin-Yu Fang, Munitta Muthana, Claire E. Lewis
      Pages 17-29
    4. Serena Zilio, Giacomo Desantis, Mariacristina Chioda, Vincenzo Bronte
      Pages 49-62
    5. Simon Hallam, Thorsten Hagemann
      Pages 63-73
  3. Mechanisms of Action

    1. Front Matter
      Pages 75-75
    2. Melissa Phillips, Peter W. Szlosarek
      Pages 77-90
    3. George C. Prendergast, Richard Metz, Mee Young Chang, Courtney Smith, Alexander J. Muller, Suzanne Ostrand-Rosenberg
      Pages 91-104
    4. Christian Stockmann, Randall S. Johnson
      Pages 105-115
  4. Molecular Regulation

    1. Front Matter
      Pages 117-117
    2. Oscar R. Colegio, Ruslan Medzhitov
      Pages 119-133
    3. Victor W. Ho, Melisa J. Hamilton, Etsushi Kuroda, Jens Ruschmann, Frann Antignano, Vivian Lam et al.
      Pages 135-151
    4. Nadine Rohwer, Thorsten Cramer
      Pages 167-181
  5. Back Matter
    Pages 183-187

About this book

Introduction

Macrophages are tissue resident phagocytes that have important roles in development and immunity. The observation that cancers become infiltrated by large numbers of macrophages was first made by Virchow in 1863, clinical and experimental studies suggest tumor-associated macrophages (TAM) are critical to promote carcinogenesis and tumor-progression, however to this day it still isn’t clear what regulates the recruitment of macrophages in tumors and what drives their pro-tumor functions. This volume will provide an overview of current research on the form and function of TAM, highlighting both the mechanistic roles they play in carcinogenesis and tumor progression as well as the molecular mechanisms that control their phenotype and function, and the final chapter addresses the issue of TAM as a potential target in cancer therapy.

Keywords

Ik-B NF-kB TLR Signaling argine metabolism myeloid cells phagocytes tumor biology

Editors and affiliations

  • Toby Lawrence
    • 1
  • Thorsten Hagemann
    • 2
  1. 1.Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology GroupCentre d'Immunologie Marseille LuminyMarseilleFrance
  2. 2.Barts & The London Queen Mary's, School of Medicine & DentistryQueen Mary, University of LondonLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-0662-4
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-0661-7
  • Online ISBN 978-1-4614-0662-4
  • About this book
Industry Sectors
Biotechnology
Pharma