New Concepts in Neurotransmitter Regulation

Proceedings of a Symposium on Drug Abuse and Metabolic Regulation of Neurotransmitters held in La Jolla, Californina, in July 1972

  • Arnold J. Mandell

Table of contents

  1. Front Matter
    Pages i-xii
  2. Neurotransmitter Regulation and Enzyme Systhesis

  3. Neurotransmitter Regulation and Enzyme Activity

    1. Edith G. McGeer, Paul L. McGeer
      Pages 53-68
    2. Norman Weiner, Frank C. Bove, Richard Bjur, Gilles Cloutier, Salomon Z. Langer
      Pages 89-113
  4. New Approaches to Neurotransmitter Regulation

  5. Multivariate Considerations in Neurotransmitter Regulation

    1. Floyd E. Bloom, Barry J. Hoffer, George R. Siggins
      Pages 223-238
    2. Jacques Glowinski, Michel Hamon, Francis Héry
      Pages 239-257
  6. Opiate Drug Effects and Neurotransmitter Regulation

  7. Back Matter
    Pages 311-316

About this book


Historically, the development of biological science has proceeded from the anatomy to the physiology of particular systems. Knowledge about neurotransmitters in the brain has evolved from the discovery of the compounds per set through the elucidation of their biosynthetic and degradative pathways, and finally to the current focus, the regulation of these processes. Regulation in a biological system implies the capacity to respond to perturbations. The introduction of standard and speci­ fiable disturbances in a biological system followed by examination of the mechanisms involved in response, i.e. that dampen and/or cancel the induced changes, has proved to be a successful way to elucidate regulatory mechanisms. Psychotropic drugs have been most useful to students of regula­ tory mechanisms in that calvarial prisoner, the brain, for they allow prospective manipulation of variables like dosage and time. Those of us interested in the biological substrata of behavior are especially excited that disturbance induced by drugs leaves the organism intact and behaving, and we can observe behavioral correlates. The pharmacological strategy is, of course, not unique to brain scientists. The relationship between psychotropic drugs and our emerging knowledge of neurotransmitter regulation is, for example, akin to the development of anticancer agents in company with the uncovering of many mysteries of molecular biology.


adenosine anatomy behavior biology brain cancer development drugs molecular biology neurons neurotransmitter pharmacology physiology regulation

Editors and affiliations

  • Arnold J. Mandell
    • 1
  1. 1.Department of Psychiatry, School of MedicineUniversity of California at San DiegoLa JollaUSA

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