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The Developing Heart

Clinical Implications of its Molecular Biology and Physiology

  • Book
  • © 1985

Overview

Editors:
  1. Marianne J. Legato

    1. Columbia University College of Physicians and Surgeons, USA

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Ultrastructural Changes in Postnatal Development of the Cardiac Myocyte

    • Margaret Ann Goldstein, Laurel Traeger
    Pages 1-20

  3. Electrophysiology of the Fetal and Neonatal Heart

    • Peter Danilo Jr.
    Pages 21-38

  4. The Development of the Electrocardiogram

    • M. Irené Ferrer
    Pages 39-46

  5. The Differentiation of the Purkinje Fibers in the Mammalian Heart — Comparisons with the Ordinary Myocytes

    • Sture Forsgren
    Pages 47-67

  6. Models of Cardiac Development: Transplants, Organ Culture, Cell Dispersion, and Cell Culture

    • Richard B. Robinson
    Pages 69-94

  7. Calcium Exchange in the Developing Myocardium

    • Glenn A. Langer, Jay M. Jarmakani
    Pages 95-111

  8. Regulation of Contractility in Developing Heart

    • Z. J. Penefsky
    Pages 113-148

  9. Isomyosin Shifts in Normal and Induced Cardiac Growth

    • Ketty Schwartz, Jean-Jacques Mercadier
    Pages 149-171

  10. Developmental and Adaptive Changes of Atrial Isomyosins

    • Stefano Schiaffino, Luisa Gorza, Saverio Sartore, Lars-Eric Thornell
    Pages 173-189

  11. The Role of Protein Synthesis and Degradation in Cardiac Growth

    • Radovan Zak
    Pages 191-203

  12. Ontogeny of Peripheral Blood Vessels

    • Kent Hermsmeyer
    Pages 205-210

  13. Hypertension in the Young

    • Suzanne Oparil
    Pages 211-243

  14. Coronary Atherosclerosis — Extension of Developmental Processes Beginning in Infancy

    • Adam Schneeweiss, Henry N. Neufeld
    Pages 245-251

  15. Back Matter

    Pages 253-256
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Keywords

About this book

Heart disease, despite recent improvements, continues to be the single most im­ portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de­ cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im­ proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl­ edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect­ ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi­ ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.

Editors and Affiliations

  • Columbia University College of Physicians and Surgeons, USA

    Marianne J. Legato

Bibliographic Information

  • Book Title: The Developing Heart

  • Book Subtitle: Clinical Implications of its Molecular Biology and Physiology

  • Editors: Marianne J. Legato

  • DOI: https://doi.org/10.1007/978-1-4613-3834-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishing, Boston 1985

  • Hardcover ISBN: 978-0-89838-672-1Published: 30 November 1984

  • Softcover ISBN: 978-1-4613-3836-9Published: 21 October 2011

  • eBook ISBN: 978-1-4613-3834-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIII, 256

  • Topics: Biochemistry, general, Cardiology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

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