Carcinomas of the Head and Neck

1. Front Matter

   Pages i-xi

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2. Advances in Staging and Primary Treatment

   1. Front Matter

      Pages 1-1

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   2. Magnetic Resonance Imaging of Head and Neck Cancer

      • Robert Lufkin, William Hanafee

      Pages 3-30

   3. Diagnostic Imaging in the Diagnosis of Malignant Invasion of the Carotid Artery: Ultrasound, Computed Tomography, Magnetic Resonance Imaging

      • Gretchen A. W. Gooding

      Pages 31-46

   4. Craniofacial Resection for Tumors of the Ethmoid and Superior Nasal Vault

      • Paul A. Levine

      Pages 47-53

   5. Surgical Resection for Recurrent Nasopharynx Cancer

      • Willard E. Fee Jr.

      Pages 55-59

   6. Advanced Basal and Squamous Cell Carcinomas of the Skin of the Head and Neck

      • Randal S. Weber, Scott M. Lippman, Marsha D. McNeese

      Pages 61-81

   7. Interstitial Hyperthermia in Head and Neck Oncology

      • Patrick L. Welton, Don R. Goffinet, Daniel S. Kapp

      Pages 83-93

   8. Photodynamic Therapy in the Management of Head and Neck Cancer

      • Jack L. Gluckman, Robert P. Zitsch

      Pages 95-113

3. Rehabilitation

   1. Front Matter

      Pages 115-115

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   2. Mechanisms for Vocal Communication Following Total Laryngectomy

      • Michael D. Trudeau, David E. Schuller

      Pages 117-131

   3. Neck Dissection: Morbidity and Rehabilitation

      • Allen Hillel, Carolynn Patten

      Pages 133-147

4. Advances in Medical Management and Chemotherapeutic Approaches

   1. Front Matter

      Pages 149-149

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   2. Evaluation and Medical Management of Thyroid Cancer

      • Margaret M. Petersen, I. Ross McDougall

      Pages 151-170

   3. Chemotherapy of Patients with Recurrent Head and Neck Cancer

      • Richard H. Wheeler

      Pages 171-193

   4. Combined Chemotherapy and Radiation for Unresectable Head and Neck Cancer

      • Samuel G. Taylor IV

      Pages 195-208

   5. The Role of Induction Chemotherapy for Organ Preservation in Laryngeal Carcinoma

      • Isaiah W. Dimery, Charles D. Wendt, Alan M. Kramer, Robert M. Byers, Waun K. Hong

      Pages 209-222

5. Basic Biology and Etiology

   1. Front Matter

      Pages 223-223

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   2. Methodology and Clinical Applications of Cellular DNA Content Parameters Determined by Flow Cytometry in Squamous Cell Cancers of the Head and Neck

      • John F. Ensley, Zosia Maciorowski, Haline Pietraszkiewicz, Filippo deBraud, Wael Sakr

      Pages 225-242

   3. Head and Neck Tumor Immunology

      • Stimson P. Schantz, Howard E. Savage, Norris K. Lee

      Pages 243-263

It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo­ therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome.

• Staging
• Tumor
• carcinoma
• computed tomography (CT)
• diagnosis
• imaging
• morbidity
• rehabilitation
• ultrasound
• Radiaton Oncology

• Division of Medical Oncology—M211, Department of Medicine, Stanford University School of Medicine, Stanford, USA

  Charlotte Jacobs

Policies and ethics