© 1997

Cytokines and Growth Factors in Blood Transfusion

Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland

  • Cees Th. Smit Sibinga
  • P. C. Das
  • Bob Löwenberg

Part of the Developments in Hematology and Immunology book series (DIHI, volume 32)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Fundamental Aspects of Cytokines and Growth Factors

  3. Role and Function of Cytokines and Growth Factors in the Blood Bank

    1. Front Matter
      Pages 47-47
    2. M. Fujihara, K. Ikebuchi, S. Yamamoto, T. Nakase, S. Sekiguchi
      Pages 49-62
    3. T. A. Bock, W. Brugger, S. Scheding, B. Ziegler, L. Kanz
      Pages 71-75
    4. D. R. Rill, D. Dilloo, M. E. Grossmann, T. Lemig, M. K. Brenner
      Pages 77-81
    5. R. Henschler, D. Möbest, F. Rosenthal, R. Mertelsmann
      Pages 83-90
    6. Back Matter
      Pages 97-102
  4. Role and Application of Cytokines and Growth Factors in Clinical Medicine

    1. Front Matter
      Pages 103-103
    2. M. E. Ressing, R. E. M. Toes, R. M. P. Brandt, E. I. H. van der Voort, J. H. de Jong, W. M. Kast et al.
      Pages 137-149

About this book


Cytokines are cellular growth factors which also provide communication between cells and their milieu. This clearly is an exciting area in modern medicine that will have significant impact on various facets of transfusion. Erythropoietin therapy stimulates red cell production while thrombopoietin seems to positively affect megakaryopoiesis and can be an added armamentarium for the thrombocytopenic patient.
Using haematnopoietic growth factors, stem cells could be mobilized early to the peripheral blood for collection and subsequent transplantation into haemato-oncology patients instead of bone marrow transplantation. Using a cocktail of cytokines in cell culture, stem cells could be expanded and selected for therapy. Cytokines and growth factors can even be modified, which may lead to successful gene therapy in malignancies, including solid tumour vaccines. However, the presence of cytokines in certain blood products could have biological effects following transfusion, although its clinical relevance needs to be ascertained. There is much potential for the use of cytokines in the treatment of infections. Early diagnostic methods are now available to monitor their levels and relevance. It is likely that cytokines will increasingly play a role in therapy and could develop our fundamental knowledge about the development of T-cells. An ethical dilemma remains, however, regarding the use of cytokines in healthy donors for harvesting suitable specific cells. Longer clinical observation will be necessary to gather the necessary information.
Cytokines and growth factors in blood transfusion was the theme of the 21st International Symposium in Blood Transfusion, where twenty clinicians and scientists, experts in their own fields, were invited to update the above information. Their findings are presented in four sections in this volume:
  • Fundamental aspects - cytokines in development of T-cells, growth factors in haematopoiesis, growth factor receptors and signal transduction, cytokine response in platelet and whole blood transfusions.
  • Function, production and diagnosis &endash; laboratory diagnostics of cytokines and growth factors, cytokines in blood components, cytokines and growth factors in cell expansions, cytokines for genetic modification towards gene therapy, progenitor cells from healthy donors.
  • Application in clinical medicine &endash; clinical relevance of cytokines in transfusion products, cytokines and growth factors in solid tumours, gene therapy in malignancies, vaccine strategies inducing T-cell immunity against tumours, cytokines in the treatment of infections, thrombopoietin and megakaryopoiesis.
  • Future potential use in transfusion medicine &endash; erythropoietin, immunotherapy, ethical aspects of the use of cytokines and growth factors in donors, potential of cytokines and growth factors in transfusion medicine.


Laboratory blood cell cytokine cytokines diagnostics gene therapy immunotherapy infection infections stem cells transfusion medicine transplantation tumor vaccine

Editors and affiliations

  • Cees Th. Smit Sibinga
    • 1
  • P. C. Das
    • 1
  • Bob Löwenberg
    • 2
  1. 1.Red Cross Blood Bank Noord NederlandThe Netherlands
  2. 2.Erasmus UniversityRotterdamThe Netherlands

Bibliographic information

  • Book Title Cytokines and Growth Factors in Blood Transfusion
  • Book Subtitle Proceedings of the Twentyfirst International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord Nederland
  • Editors C.Th. Smit Sibinga
    P.C. Das
    B. Löwenberg
  • Series Title Developments in Hematology and Immunology
  • DOI
  • Copyright Information Springer-Verlag US 1997
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-7923-4787-3
  • Softcover ISBN 978-1-4612-8435-2
  • eBook ISBN 978-1-4613-1137-9
  • Edition Number 1
  • Number of Pages XIV, 206
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Laboratory Medicine
Industry Sectors
Health & Hospitals
Oncology & Hematology


`Well referenced throughout, this monograph then is a unique collection of the current research and discussion on this important topic. Of particular value to transfusion specialist clinicians and medical scientists, this monograph would also be of interest to haematology specialists and scientists, and researchers in these fields.'
Australian Journal of Medical Science, 20:3 (1999)