Protein Structure — Function Relationship

1. Front Matter

   Pages i-xi

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2. How is the Dioxygen-Iron Bond Manipulated by Transport and Catalytic Haem Proteins?

   • M. Akhtar

   Pages 1-12

3. A New Flow Modulated Continuous Bioreactor Based on Inversed Capillary Membranes for Low Risk Gene Technology

   • Hermann Bauer, Udo Promm, Wilhelm Schumann, Peter Bendzko

   Pages 13-16

4. Characterization and Substrate Specificities of Various Mouse Kallikreins

   • Obaid U. Beg, Mukarram Uddin

   Pages 17-23

5. Natural Occurence of Enzymes Linked to Inorganic Supports

   • N. Sabil, Y. Aissouni, B. Pavoni, D. Tagliapietra, M.-A. Coletti-Previero

   Pages 25-43

6. New Developments on Human Milk Protein Composition and Function

   • Amedeo Conti, Gabriella Giuffrida, Maria Cavaletto, Carlo Giunta

   Pages 45-49

7. Structure-Function of Two Membrane Protein Systems Involved in Transfer of Electrical Charge

   • W. A. Cramer, J. B. Heymann, D. Huang, S. E. Martinez, S. L. Schendel, J. L. Smith

   Pages 51-59

8. β,γ-Crystallins

   • Huub Driessen

   Pages 61-69

9. The Use of Metal Ions as Spectroscopic Probes in the Elucidation of pKa’s of Small Molecules

   • Bijan Farzami

   Pages 71-80

10. Trypsin Complexed with α1-Proteinase Inhibitor Has an Increased Structural Flexibility

    • Gyula Kaslik, András Patthy, Miklós Bálint, László Gráf

    Pages 81-89

11. Structures and Functions of Leginsulin and Leginsulin-Binding Protein

    • Hisashi Hirano

    Pages 91-96

12. From Structure to Therapy?

    • L. N. Johnson

    Pages 97-108

13. New Insights into the Molecular Structure of the Agonists Binding Site of Protein Kinase C by Pseudoreceptor Modeling

    • G. Krauter, C. W. von der Lieth, E. Hecker

    Pages 109-122

14. The Use of Synchrotron Radiation in Protein Crystallography

    • Peter F. Lindley

    Pages 123-133

15. NMR Approaches to the Study of Structure-Function Relationships in Iron-Sulfur Proteins

    • John L. Markley, Bin Xia, Young Kee Chae, Hong Cheng, William M. Westler, Jeremie D. Pikus et al.

    Pages 135-146

16. Thermodynamic Views of Inhibition, Activation and Denaturation of Adenosine Deaminase by Ring Opened Nucleosides and Denaturants

    • Ali A. Moosavi-Movahedi

    Pages 147-156

17. Domain Motions in Protein Crystals

    • David Moss, Andrej Šali, Christine Slingsby, Alan Simpson, Andreas Wostrack

    Pages 157-165

18. Interaction of Bovine Serum Albumin and Hexadecyl Pyridinium Bromide Study by Surfactant Selective Electrode and Spectrophotometry

    • Hossain Naderimanesh, Nader Alizadeh, Mojtabah Shamsipoor

    Pages 167-174

19. Ciliate Telomere Proteins

    • Carolyn M. Price

    Pages 175-182

20. Diverse Actions of Human Lipoproteins on Arachidonic Acid Metabolism

    • Sheikh A. Saeed, Riaz A. Memon, Anwar H. Gilani

    Pages 183-191

Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth's chemistry and biology to improve the quality of life for mankind. Immediately goals of this area of research include identification of the life-supporting functions of proteins, and the fundamental forces that facilitate these functions. Upon reaching these goals, we shall have the understanding to direct and the tools required to implement changes that will dramatically improve the quality of life. For example, under­ standing the chemical mechanism of diseases will facilitate development of new therapeutic drugs. Likewise, understanding of chemical mechanisms of plant growth will be used with biotechnology to improve food production under adverse climatic conditions. The challenge to understand details of protein structure/function relationships is enormous and requires an international effort for success. To direct the chemistry and biology of our environment in a positive sense will require efforts from bright, imaginative scientists located throughout the world. Although the emergence of FAX, e-mail, and the World Wide Web has revolutionized international communication, there remains a need for scientists located in distant parts of the world to occasionally meet face to face.

• development
• enzymes
• protein
• receptor
• transport

• H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan

  Zafar H. Zaidi

• Department of Chemistry, University of Nebraska, Lincoln, USA

  David L. Smith

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