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Drug Discovery and Development

  • Book
  • © 1987

Overview

Editors:
  1. Michael Williams

    1. Drug Discovery Administration, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jeffrey B. Malick

    1. Biomedical Research Department, Stuart Pharmaceuticals, ICI Americas Inc., Wilmington, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Overview

    1. Front Matter

      Pages 1-1
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    2. Drug Discovery and Development

      • Michael Williams, Jeffrey B. Malick
      Pages 3-29

  3. Compound Discovery

    1. Front Matter

      Pages 31-31
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    2. Drug Design

      • John J. Baldwin
      Pages 33-71

    3. Computer-Based Approaches to Drug Design

      • Philip Loftus, Marvin Waldman, Robert F. Hout Jr.
      Pages 73-96

    4. Use of Intact Tissue Preparations in the Drug Discovery Process

      • Frank R. Goodman
      Pages 97-113

    5. Neuropsychopharmacological Drug Development

      • Jeffrey B. Malick
      Pages 115-149

    6. Biochemical Approaches for Evaluating Drug—Receptor Interactions

      • S. J. Enna
      Pages 151-176

    7. Drug Discovery at the Enzyme Level

      • Ray W. Fuller, Larry R. Steranka
      Pages 177-198

    8. EEG, EEG Power Spectra, and Behavioral Correlates of Opioids and Other Psychoactive Agents

      • Gerald A. Young, Oksoon Hong, Naim Khazan
      Pages 199-226

    9. Immunopharmacological Approaches to Drug Development

      • Steven C. Gilman, Alan J. Lewis
      Pages 227-256

  4. Toxicological Evaluation and Clinical Aspects

    1. Front Matter

      Pages 257-257
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    2. Toxicological Evaluation of Drugs

      • Joy Cavagnaro, Richard M. Lewis
      Pages 259-289

    3. Drug Delivery Systems

      • Joseph V. Bondi, D. G. Pope
      Pages 291-325

    4. Clinical Evaluation of Drug Candidates

      • Scott A. Reines, Dick Fong
      Pages 327-350

  5. Therapeutic Entities — From Discovery to Human Use

    1. Front Matter

      Pages 351-351
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    2. Cimetidine and Other Histamine H2-Receptor Antagonists

      • Roger W. Brimblecombe, C. Robin Ganellin
      Pages 353-385

    3. Atypical Psychotropic Agents

      • Michael S. Eison, Duncan P. Taylor, Leslie A. Riblet
      Pages 387-407

    4. Calcium Channel Antagonists

      • Robert J. Gould
      Pages 409-442
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Keywords

Editors and Affiliations

  • Drug Discovery Administration, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, USA

    Michael Williams

  • Biomedical Research Department, Stuart Pharmaceuticals, ICI Americas Inc., Wilmington, USA

    Jeffrey B. Malick

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