Lactoferrin

1. Front Matter

   Pages i-xvi

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2. Lactoferrin Structure and Function

   1. Front Matter

      Pages 1-1

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   2. Lactoferrin Structure-Function Relationships

      • Jeremy H. Brock

      Pages 3-23

   3. Altered Domain Closure and Iron Binding in Lactoferrin Mutants

      • H. Rick Faber, Bryan F. Anderson, Heather M. Baker, Tony Bland, Catherine L. Day, Hale Nicholson et al.

      Pages 25-38

   4. Affinity Mass Spectrometry

      • Tai-Tung Yip, T. William Hutchens

      Pages 39-58

3. Lactoferrin Gene Expression

   1. Front Matter

      Pages 59-59

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   2. Variants and Biotechnological Use of the Bovine Lactoferrin-Encoding Gene

      • Hans-Martin Seyfert, Uta Klußmann, Uta Maria Steinhoff, Jens Vanselow, Dirk Koczan, Gerd Hobom

      Pages 61-79

   3. Posttranscriptional Regulation of Bovine and Human Lactoferrin

      • Floyd L. Schanbacher, Surapon Pattanajitvilai, Margaret C. Neville

      Pages 81-95

   4. Mutagenesis of Human Lactoferrin and Expression in Baby Hamster Kidney Cells

      • John W. Tweedie, Edward N. Baker, Catherine L. Day, Bhavwanti Sheth, H. Hale Nicholson

      Pages 97-110

   5. Structural Determination of Two N-Linked Glycans Isolated from Recombinant Human Lactoferrin Expressed in BHK Cells

      • Dominique Legrand, Valérie Salmon, Bernadette Coddeville, Monique Benaïssa, Yves Plancke, Geneviève Spik

      Pages 111-117

   6. Distribution of the Iron-Binding Protein Lactoferrin in the Pathological Lesions of Neurodegenerative Diseases

      • Béatrice Leveugle, Geneviève Spik, Daniel P. Perl, Constantin Bouras, Howard M. Fillit, Patrick R. Hof

      Pages 119-124

   7. Lactoferrin Almost Absent from Lactating Rat Mammary Gland is Replaced by Transferrin

      • Annick Pierce, Hector Escriva, Bernadette Coddeville, Monique Benaïssa, Didier Leger, Geneviève Spik et al.

      Pages 125-134

   8. Estrogen Regulation of Human Lactoferrin Gene Activity

      • Christina T. Teng, Nengyu Yang

      Pages 135-153

   9. Expression and Functional Analysis of Recombinant Human Lactoferrin

      • Pauline P. Ward, Christopher S. Piddington, Grainne Cunningham, Xiaodong Zhou, Roger D. Wyatt, Orla M. Conneely

      Pages 155-176

   10. Structural and Functional Flexibility of Lactoferrin

       • Edward N. Baker, Bryan F. Anderson, Heather M. Baker, H. Rick Faber, Clyde A. Smith, Andrew J. Sutherland-Smith

       Pages 177-191

   11. Difference in Binding and Fate of Lactotransferrin in Jurkat Human Lymphoblastic T-Cells and in T-47D Human Breast Cancer Cells

       • Bao Yuan Bi, Elisabeth Elass, Dominique Legrand, Florence Deplace, Geneviève Spik, Joël Mazurier

       Pages 193-209

   12. The Impact of Phagocyte—Lactoferrin Interactions on Inflammation

       • Bradley E. Britigan, Troy S. Lewis, Oyebode Olakanmi, Michael L. McCormick, Rachel A. Miller

       Pages 211-232

   13. Regulation of Lymphocyte Proliferation by Lactoferrin

       • Jeremy H. Brock, Abdelhakim Djeha

       Pages 233-243

   14. Recombinant Human Lactoferrin and Its Variants

       • Suhasini Iyer, Bo Lönnerdal, Catharine L. Day, Edward N. Baker, John W. Tweedie, Tai-Tung Yip et al.

       Pages 245-256

4. Functions Related to Lactoferrin Interactions with Prokaryotic and Eukaryotic Cells

   1. Front Matter

      Pages 257-257

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The number of investigators focusing their attention on lactoferrin has increased dramatically in recent years. Lactoferrin is a protein with more than one known structure and a number of proposed biological functions, including several with important regulatory consequences. In many ways it has been an easy pro­ tein to investigate; however, there have been difficulties under­ standing specific structure / function relationships, particularly as it functions in vivo. Research funding dedicated to this protein has previously been limited, but is now increasing. As lactoferrin begins to emerge formally as a protein of significance to the medi­ and industry, it is more important than ever to coor­ cal profession dinate and integrate research efforts whenever possible and to share the results of these efforts within the expanding array of medical and scientific diSciplines involved. It was our intention to provide a forum to summarize and disseminate the most recent advances in this field. Included in Lactoferrin: Interactions and Biological Functions are selected presentations representing the many disciplines involved in defining lactoferrin function in terms of its known structural features, including its carbohydrate side-chains, receptor binding sites, its capacity to bind different metal ions, and other newly discovered bioactive domains. Several of the possible physiologi­ cal functions of lactoferrin are described and summarized in detail, including the role of laetoferrin in bacterial killing, its in­ volvement in cell growth and proliferation, in the modulation of immune function, and in iron absorption.

• Expression
• Leishmania
• gene expression
• influence
• metabolism
• mutagenesis
• protein
• regulation
• transcription

• Department of Food Science and Technology, University of California, Davis, USA

  T. William Hutchens

• Department of Nutrition, University of California, Davis, USA

  Bo Lönnerdal

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