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NMR: Principles and Applications to Biomedical Research

  • Book
  • © 1990

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Editors:
  1. Jay W. Pettegrew

    1. The Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Principles of Pulse NMR Spectroscopy

    • T. C. Farrar
    Pages 1-36

  3. Relaxation Theory with Applications to Biological Studies

    • D. E. Woessner
    Pages 37-67

  4. Two-Dimensional Fourier Transform NMR: Homonuclear and Heteronuclear Couplings-Multiple Quantum Filtering

    • A. A. Bothner-By
    Pages 68-78

  5. High-Resolution NMR of Solids

    • J. S. Frye
    Pages 79-98

  6. Artificial Intelligence Techniques and NMR Spectroscopy: Application to the Structure of Proteins in Solution

    • B. S. Duncan, J. F. Brinkley, R. B. Altman, B. G. Buchanan, O. Jardetzky
    Pages 99-123

  7. Application of Solid State NMR to the Lipids of Model and Biological Membranes

    • I. C. P. Smith
    Pages 124-156

  8. Application of 31P NMR to Eye Research

    • T. Glonek, J. V. Greiner, J. H. Lass
    Pages 157-203

  9. 31P NMR of Brain Aging and Alzheimer’s Disease

    • J. W. Pettegrew, G. Withers, K. Panchalingam
    Pages 204-254

  10. NMR Spectroscopy of Tumors

    • J. D. Glickson, J. P. Wehrle, S. S. Rajan, S. J. Li, R. G. Steen
    Pages 255-309

  11. Solid State 31P and 27Al NMR Studies of Model Membranes and Mammalian Brain: Possible Implications for Alzheimer’s Disease

    • J. W. Pettegrew, K. Panchalingam
    Pages 310-354

  12. 23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease

    • J. W. Pettegrew, D. E. Woessner
    Pages 355-400

  13. Theory and Technique of Surface Coils in In Vivo Spectroscopy

    • M. R. Bendall
    Pages 401-428

  14. 31P in vivo Spectroscopy of Adult Human Brain

    • K. M. A. Welch
    Pages 429-467

  15. 1H-NMR Spectroscopy of Brain

    • G. A. Rosenberg, E. Kyner, C. Gasparovic, R. H. Griffey, N. A. Matwiyoff
    Pages 468-484

  16. Nuclear Magnetic Resonance and Cell pH with a Focus on Brain pH

    • S. Adler
    Pages 485-505

  17. Introduction to NMR Imaging

    • I. J. Lowe
    Pages 506-521

  18. NMR Imaging: Techniques and Developments

    • J. C. Gore
    Pages 522-535

  19. Contrast Media for MRI: Present and Future Applications

    • G. L. Wolf
    Pages 536-549

  20. NMR Imaging of the Human Brain-Insights into Neurological Diseases

    • R. E. Latchaw
    Pages 550-585
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Keywords

About this book

Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who demonstrated that a beam of hydrogen molecules in the presence of a magnetic field could be mutated by radio frequency fields resonating at the Iarmor frequency. 'Ihe first successful NMR experiments in condensed matter were independently conducted in late 1945 by Purcell, Torrey and PoUnd and by Bloch, Hansen and Packard. 'Ihe Purcell group detected proton NMR in solid paraffin and the Bloch group detected proton in liquid water. Bloch and Purcell received the Nobel Prize in physics in 1952 for these observations . Until about 1952, studies of liquids and solids with broad resonance lines dominated the field of NMR. However, the reports of 3 1 P NMR chemical shifts in several corrpounds in 1949 by Khight, of 14 N resonances in several ions by Proctor and Yu in 1950, and of 1 9 F resonances in several corrpounds in 1950 by Dickinson led to the development of high resolution NMR in Itquids. since the molecular motions in liquids result in very narrow lines compared to those in solids, :much smaller chemical shifts could be detected.

Editors and Affiliations

  • The Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA

    Jay W. Pettegrew

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