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Autoimmunity and the Pathogenesis of Diabetes

  • Book
  • © 1990

Overview

Editors:
  1. Fredda Ginsberg-Fellner

    1. Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

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  2. Robert C. McEvoy

    1. Mount Sinai School of Medicine, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Endocrinology and Metabolism (EAM, volume 4)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present

    • Thomas Mandrup-Poulsen, Jørn Nerup
    Pages 1-28

  3. Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus

    • Pablo Rubinstein
    Pages 29-55

  4. Association of Insulin-Dependent Diabetes Mellitus and Other Autoimmune Diseases

    • Fredda Ginsberg-Fellner
    Pages 56-67

  5. The Humoral Anti-Islet Immune Response: Cytoplasmic Islet-Cell Antibodies: Technical Aspects and Clinical Applications

    • Helga Gleichmann, Gian Franco Bottazzo
    Pages 68-86

  6. The Humoral Anti-Islet Response: Biochemical Characterization

    • Heike Bärmeier, Michael Christie, Betsy Herold, Kevan Herold, Ã…ke Lernmark
    Pages 87-104

  7. The Humoral Anti-Islet Immune Response: Immunochemical Studies of Glycoconjugate Antigens

    • R. C. Nayak, G. S. Eisenbarth
    Pages 105-146

  8. Insulin Autoantibodies

    • Jerry P. Palmer
    Pages 147-164

  9. Cell-Mediated Anti-Islet—Cell Immune Response: Clinical Experience and Lessons from Animal Models

    • Robert C. McEvoy, Nancy M. Thomas
    Pages 165-183

  10. The Pathogenesis of Immunologically Mediated Diabetes

    • Yi Wang, Liming Hao, Kevin J. Lafferty
    Pages 184-205

  11. Viral Pathogenesis of Insulin-Dependent Diabetes Mellitus

    • Ji-Won Yoon
    Pages 206-255

  12. Immune Intervention in Diabetes: State of the Art and Future Directions

    • J. Dupré, C. R. Stiller
    Pages 256-281

  13. Back Matter

    Pages 283-296
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Keywords

About this book

It has been a challenge for us to edit this volume of Endocrinology and Metabo­ lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des­ truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the progression of diabetes with immunosuppressive drugs. New York, New York Fredda Ginsberg-Fellner Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . . . . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . 1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . . . . . . ..................... . . . . . .

Editors and Affiliations

  • Division of Pediatric Endocrinology and Metabolism, Mount Sinai School of Medicine, New York, USA

    Fredda Ginsberg-Fellner

  • Mount Sinai School of Medicine, New York, USA

    Robert C. McEvoy

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