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  • Conference proceedings
  • © 1993

Trophoblast Cells

Pathways for Maternal-Embryonic Communication

Part of the book series: Serono Symposia USA (SERONOSYMP)

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Table of contents (20 papers)

  1. Front Matter

    Pages i-xxi
  2. All in the Family: The Growth Hormone, Prolactin, and Placental Lactogen Triad

  3. Trophoblast Development and Organization

    1. Front Matter

      Pages 11-11
    2. Development and Organization of Primate Trophoblast Cells

      • Barry F. King, Thomas N. Blankenship
      Pages 13-30
    3. Trophoblast Cell Differentiation: Expression of the Placental Prolactin Family

      • Michael J. Soares, Teresa N. Faria, Gary P. Hamlin, Xing-Jian Lu, Santanu Deb
      Pages 45-67
  4. Trophoblast-Uterine Interactions

    1. Front Matter

      Pages 69-69
    2. Cell Interactions in Trophoblast Invasion

      • John D. Aplin, Ljiljana Vićovac, Abdul Sattar
      Pages 92-108
    3. Cytotrophoblast Expression of Integrin Extracellular Matrix Receptors Is Altered in Preeclampsia

      • Yan Zhou, Caroline H. Damsky, King Chiu, James M. Roberts, Susan J. Fisher
      Pages 109-122
    4. Autocrine/Paracrine Regulation of Decidual Prolactin Expression

      • Stuart Handwerger, Randall G. Richards, Susan E. Myers
      Pages 134-150
    5. Human Trophoblast-Uterine Immunological Interactions

      • Y. W. Loke, Ashley King, Gill Chumbley
      Pages 151-159
  5. Biology of Trophoblast Cell Signaling Systems

    1. Front Matter

      Pages 161-161
    2. Mouse Placental Lactogens: Characterization and Regulation of Expression in Trophoblast Cells

      • Frank Talamantes, Masaaki Yamaguchi, Gudmundur Thordarson, Jonathan Southard, Linda Ogren
      Pages 163-168
    3. Molecular Genetics and Biology of the Rat Placental Prolactin Family

      • Mary Lynn Duckworth, May C. Robertson, Ingo C. Schroedter, Claude Szpirer, Henry G. Friesen
      Pages 169-190
    4. Molecular Genetics and Biology of the Bovine Placental Prolactin Family

      • Linda A. Schuler, Patricia Scott, Mark A. Kessler
      Pages 191-205
    5. Trophoblast Interferons: Expression During Development and Gene Organization

      • R. Michael Roberts, Douglas W. Leaman, Jose Juan Hernandez-Ledezma, Neal C. Cosby
      Pages 206-221
    6. Placental Expression and Function of the Human Growth Hormone Gene Cluster

      • N. E. Cooke, B. K. Jones, M. Urbanek, A. Misra-Press, A. K. Lee, J. E. Russell et al.
      Pages 222-239
  6. Regulation of Trophoblast Gene Expression

    1. Front Matter

      Pages 241-241

About this book

Trophoblast cells coordinate the activities of maternal and embryonic tissues by secreting hormones, cytokines, and various growth factors that selectively and specifically gain access to maternal and embryonic compartments. Abnormalities associated with trophoblast cell growth, differentiation, or function result in impaired embryonic development. Understanding the complexities of the trophoblast cell signaling system was the focus of the Serono Symposia, USA conference entitled Tropho­ blast Cells: Pathways for Maternal-Embryonic Communication, held August 6-9, 1992, in Las Vegas, Nevada. The conference was designed to provide a forum for morphologists, cell biologists, endocrinologists, and molecular biologists and for scientists investigating primate, ru­ minant, and rodent trophoblast biology. An important outcome of the conference was the communication achieved between basic scientists and clinicians. This volume represents the contributions of the invited symposium speakers. The opening keynote address of the conference was entitled "Chorio­ carcinoma and the Embryo" and was presented by G. Barry Pierce, M. D. , Centennial Distinguished Research Professor of the University of Colorado School of Medicine. The address is not represented in this volume, but deserves a special comment. Dr. Pierce's scientific con­ tributions have significantly influenced our understanding of trophoblast cells. Dr. Pierce, together with Dr. A. Rees Midgley, identified the origin of syncytial trophoblast cells of the primate placenta and discovered that these cells were responsible for the production of chorionic gonadotropin (J Exp Med 1962;115:289-94; Am J Pathol 1963;43:929-43; and Science 1963;141:349-50).


  • cell
  • embryo
  • genetics
  • hormones
  • molecular genetics
  • placenta
  • regulation
  • tissue

Editors and Affiliations

  • Department of Physiology, University of Kansas Medical Center, Kansas City, USA

    Michael J. Soares

  • Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz, USA

    Frank Talamantes

  • Division of Endocrinology, Children’s Hospital Medical Center, Cincinnati, USA

    Stuart Handwerger

Bibliographic Information

  • Book Title: Trophoblast Cells

  • Book Subtitle: Pathways for Maternal-Embryonic Communication

  • Editors: Michael J. Soares, Frank Talamantes, Stuart Handwerger

  • Series Title: Serono Symposia USA

  • DOI:

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1993

  • Softcover ISBN: 978-1-4612-7641-8

  • eBook ISBN: 978-1-4612-2718-2

  • Edition Number: 1

  • Number of Pages: XXI, 315

  • Topics: Gynecology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • ISBN: 978-1-4612-2718-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 169.99
Price excludes VAT (USA)