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Multiple Organ Failure

Pathophysiology, Prevention, and Therapy

  • Book
  • © 2000

Overview

Editors:
  1. Arthur E. Baue

    1. Department of Surgery, St. Louis University Hospital, St. Louis, USA

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  2. Eugen Faist

    1. Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Donald E. Fry

    1. Department of Surgery, School of Medicine, University of New Mexico, New Mexico, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (73 chapters)

  1. Mediators and Effectors

    1. Counterregulation of Severe Inflammation: When More is Too Much and Less is Inadequate

      • Vishnu Rumalla, Stephen F. Lowry
      Pages 155-166

    2. Reactive Oxygen Species in Clinical Practice

      • Aruna Nathan, Mervyn Singer
      Pages 167-175

    3. Nitric Oxide as a Modulator of Sepsis: Therapeutic Possibilities

      • A. Neil Salyapongse, Timothy R. Billiar
      Pages 176-187

    4. Mast Cells

      • Donald E. Fry
      Pages 188-195

    5. Eicosanoids

      • Geoffrey T. Manley, Mary J. Vassar, James W. Holcroft
      Pages 196-203

    6. Platelet-Activating Factor

      • M. Poeze, W. A. Buurman, G. Ramsay, J. W. M. Greve
      Pages 204-213

    7. Therapeutic Complement Inhibition

      • Katrin Jurianz, Michael Kirschfink
      Pages 214-223

    8. Leukocyte—Endothelial Cell Interactions: Review of Adhesion Molecules and Their Role in Organ Injury

      • Milind S. Shrotri, James C. Peyton, William G. Cheadle
      Pages 224-240

  2. Prevention and General Therapy

    1. Front Matter

      Pages 241-241
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    2. Care of Injured Patients in the Field, During Transport, and in the Emergency Department

      • Steffen Ruchholtz, Christian Waydhas, Dieter Nast-Kolb
      Pages 243-253

    3. Intensive Care Monitoring

      • Orlando C. Kirton, Joseph M. Civetta
      Pages 254-263

    4. Peritonitis: Management of the Patient with SIRS and MODS

      • Donald E. Fry
      Pages 264-272

    5. Hypothermia-Coagulopathy-Acidosis Syndrome: When to Operate/When to Stop Operating

      • Asher Hirshberg, Kenneth L. Mattox
      Pages 273-278

    6. Early Definitive Fracture Fixation with Polytrauma: Advantages Versus Systemic/Pulmonary Consequences

      • Hans-Christoph Pape, Harald Tscherne
      Pages 279-290

    7. Abdominal Compartment Syndrome

      • Eduardo Bumaschny, Alejandro Rodríguez
      Pages 291-302

    8. SIRS and MODS: Indications for Surgical Intervention?

      • Donald E. Fry
      Pages 303-308

    9. Nosocomial Infections in the ICU

      • Gina Quaid, Joseph S. Solomkin
      Pages 309-321

    10. Modulation of the Hypermetabolic Response After Trauma and Burns

      • Art Sanford, David N. Herndon
      Pages 322-329

  3. Specific Remote Organ Failures

    1. Front Matter

      Pages 331-331
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    2. Circulation

      • Jean-Louis Vincent
      Pages 333-339
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Keywords

About this book

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

Reviews

"As multiple organ dysfunction remains the significant cause of ICU mortality, this textbook, the leading secondary source on this problem, is an important contribution." Doody's Reviews

Editors and Affiliations

  • Department of Surgery, St. Louis University Hospital, St. Louis, USA

    Arthur E. Baue

  • Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany

    Eugen Faist

  • Department of Surgery, School of Medicine, University of New Mexico, New Mexico, USA

    Donald E. Fry

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