Metabonomics and Gut Microbiota in Nutrition and Disease

  • Sunil Kochhar
  • François-Pierre Martin

Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. François-Pierre Martin, Sunil Kochhar
    Pages 1-24
  3. Sebastiano Collino, François-Pierre Martin, Sofia Moco
    Pages 25-44
  4. Velitchka V. Mihaleva, Fatma Yelda Ünlü, Jacques Vervoort, Lars Ridder
    Pages 109-124
  5. J. Bruce German, Jennifer T. Smilowitz, Carlito B. Lebrilla, David A. Mills, Samara L. Freeman
    Pages 147-167
  6. Elena Biagi, Marco Candela, François-Pierre Martin, Sebastiano Collino, Claudio Franceschi, Patrizia Brigidi
    Pages 169-184
  7. Rémy Burcelin, Michael Courtney, Jacques Amar
    Pages 199-234
  8. Isabel Bondia-Pons, Tuulia Hyötyläinen, Matej Orešič
    Pages 235-260
  9. Ivan K. S. Yap, François-Pierre Martin
    Pages 311-322
  10. Ian D. Wilson, Jeremy K. Nicholson
    Pages 323-341
  11. Sunil Kochhar, François-Pierre Martin
    Pages E1-E8
  12. Back Matter
    Pages 371-375

About this book

Introduction

This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition.

The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors, and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans.

Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established.

Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.

 

Keywords

gut microbiota metabolic metabolomic microbiome microbiota systems biology

Editors and affiliations

  • Sunil Kochhar
    • 1
  • François-Pierre Martin
    • 2
  1. 1.Analytical Sciences Competence PillarNestec SA, Nestlé Research CenterLausanneSwitzerland
  2. 2. Molecular BiomarkersNestlé Institute of Health SciencesLausanneSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4471-6539-2
  • Copyright Information Springer-Verlag London 2015
  • Publisher Name Springer, London
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4471-6538-5
  • Online ISBN 978-1-4471-6539-2
  • Series Print ISSN 2168-4219
  • Series Online ISSN 2168-4235
  • About this book
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