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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development

A Focus on Early Phase Clinical Studies

  • Andrew J. Krentz
  • Lutz Heinemann
  • Marcus Hompesch

Table of contents

  1. Front Matter
    Pages i-xii
  2. Review of Clinical Investigation Methodologies

    1. Front Matter
      Pages 1-1
    2. Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch
      Pages 3-43
    3. Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch
      Pages 45-69
    4. Carine Beysen, Marc K. Hellerstein, Scott M. Turner
      Pages 71-97
    5. Gavin Hamilton, Michael S. Middleton, Elhamy R. Heba, Claude B. Sirlin
      Pages 99-119
    6. Mark Punyanitya, Paul R. Clark
      Pages 139-167
    7. Klaas R. Westerterp
      Pages 169-187
    8. Harald Grallert, Carola S. Marzi, Stefanie M. Hauck, Christian Gieger
      Pages 189-222
  3. Emerging and Complementary Research Methods; Ethical and Regulatory Considerations

    1. Front Matter
      Pages 223-223
    2. Linda A. Morrow, Andrew J. Krentz
      Pages 225-242
    3. Puneet Gaitonde, Shannon A. Miller, Mirjam N. Trame, Stephan Schmidt
      Pages 243-264
  4. Back Matter
    Pages 305-312

About this book

Introduction

This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease.

Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward.

This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development.  Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders.

Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development  will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Keywords

cardiometabolic efficacy glucose clamp insulin resistance obesity type 2 diabetes

Editors and affiliations

  • Andrew J. Krentz
    • 1
  • Lutz Heinemann
    • 2
  • Marcus Hompesch
    • 3
  1. 1.Profil Institute for Clinical ResearchChula VistaUSA
  2. 2.Profil Institute for Clinical ResearchChula VistaUSA
  3. 3.Profil Institute for Clinical ResearchChula VistaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4471-4920-0
  • Copyright Information Springer-Verlag London 2015
  • Publisher Name Springer, London
  • eBook Packages Medicine
  • Print ISBN 978-1-4471-4919-4
  • Online ISBN 978-1-4471-4920-0
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology