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Innate Immune Regulation and Cancer Immunotherapy

  • Book
  • © 2012

Overview

Editors:
  1. Rongfu Wang

    1. Center for Cell & Gene Therapy, Baylor College of Medicine, Houston, USA

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  • This book will discuss recent progress in innate immunity and Treg cells

  • This book will discuss the regulation of innate immunity through Toll-like receptor (TLR) signaling

  • Additionally, this book will offer an overview of recent developments in topics of cancer immunotherapy

  • Includes supplementary material: sn.pub/extras

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • Rong-Fu Wang
    Pages 1-5

  3. The Role of NKT Cells in the Immune Regulation of Neoplastic Disease

    • Jessica J. O’Konek, Masaki Terabe, Jay A. Berzofsky
    Pages 7-21

  4. γδ T Cells in Cancer

    • Lawrence S. Lamb Jr.
    Pages 23-38

  5. Toll-Like Receptors and Their Regulatory Mechanisms

    • Shin-Ichiroh Saitoh
    Pages 39-49

  6. Cytoplasmic Sensing of Viral Double-Stranded RNA and Activation of Innate Immunity by RIG-I-Like Receptors

    • Mitsutoshi Yoneyama, Takashi Fujita
    Pages 51-60

  7. Innate Immune Signaling and Negative Regulators in Cancer

    • Helen Y. Wang, Rong-Fu Wang
    Pages 61-88

  8. Dendritic Cell Subsets and Immune Regulation

    • Meredith O’Keeffe, Mireille H. Lahoud, Irina Caminschi, Li Wu
    Pages 89-119

  9. Human Dendritic Cells in Cancer

    • Gregory Lizée, Michel Gilliet
    Pages 121-145

  10. Regulatory T Cells in Cancer

    • Tyler J. Curiel
    Pages 147-173

  11. Relationship Between Th17 and Regulatory T Cells in the Tumor Environment

    • Ilona Kryczek, Ke Wu, Ende Zhao, Guobin Wang, Weiping Zou
    Pages 175-193

  12. Mechanisms and Control of Regulatory T Cells in Cancer

    • Bin Li, Rong-Fu Wang
    Pages 195-216

  13. Myeloid-Derived Suppressor Cells in Cancer

    • Wiaam Badn, Vincenzo Bronte
    Pages 217-229

  14. Myeloid-Derived Suppressive Cells and Their Regulatory Mechanisms in Cancer

    • Ge Ma, Ping-Ying Pan, Shu-Hsia Chen
    Pages 231-250

  15. Cell Surface Co-signaling Molecules in the Control of Innate and Adaptive Cancer Immunity

    • Stasya Zarling, Lieping Chen
    Pages 251-266

  16. Negative Regulators of NF-κB Activation and Type I Interferon Pathways

    • Caroline Murphy, Luke A. J. O’Neill
    Pages 267-287

  17. Role of TGF-β in Immune Suppression and Inflammation

    • Joanne E. Konkel, WanJun Chen
    Pages 289-301

  18. Indoleamine 2,3-Dioxygenase and Tumor-Induced Immune Suppression

    • David H. Munn
    Pages 303-318

  19. Myeloid-Derived Suppressor Cells in Cancer: Mechanisms and Therapeutic Perspectives

    • Paulo C. Rodríguez, Augusto C. Ochoa
    Pages 319-334

  20. Human Tumor Antigens Recognized by T Cells and Their Implications for Cancer Immunotherapy

    • Ryo Ueda, Tomonori Yaguchi, Yutaka Kawakami
    Pages 335-345
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Keywords

About this book

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

Editors and Affiliations

  • Center for Cell & Gene Therapy, Baylor College of Medicine, Houston, USA

    Rongfu Wang

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