Bioreaction Engineering Principles

1. Front Matter

   Pages i-xxx

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2. What Is This Book About?

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 1-5

3. Chemicals from Metabolic Pathways

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 7-62

4. Elemental and Redox Balances

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 63-118

5. Thermodynamics of Bioreactions

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 119-150

6. Biochemical Reaction Networks

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 151-214

7. Enzyme Kinetics and Metabolic Control Analysis

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 215-269

8. Growth Kinetics of Cell Cultures

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 271-357

9. Population Balance Equations

   • John Villadsen, Jens Nielsen, Gunnar Lidén

   Pages 359-381

10. Design of Fermentation Processes

    • John Villadsen, Jens Nielsen, Gunnar Lidén

    Pages 383-458

11. Gas–Liquid Mass Transfer

    • John Villadsen, Jens Nielsen, Gunnar Lidén

    Pages 459-496

12. Scale-Up of Bioprocesses

    • John Villadsen, Jens Nielsen, Gunnar Lidén

    Pages 497-546

13. Back Matter

    Pages 547-561

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The present text is a complete revision of the 2nd edition from 2003 of the book with the same title. In recognition of the fast pace at which biotechnology is moving we have rewritten several chapters to include new scientific progress in the field from 2000 to 2010. More important we have changed the focus of the book to support its use, not only in universities, but also as a guide to design new processes and equipment in the bio-industry. A new chapter has been included on the prospects of the bio-refinery to replace many of the oil- and gas based processes for production of especially bulk chemicals. This chapter also serves to make students in Chemical Engineering and in the Bio-Sciences enthusiastic about the whole research field. As in previous editions we hope that the book can be used as textbook for classes, even at the undergraduate level, where chemical engineering students come to work side by side with students from biochemistry and microbiology. To help the chemical engineering students Chapter 1 includes a brief review of the most important parts of microbial metabolism. In our opinion this review is sufficient to understand microbial physiology at a sufficiently high level to profit from the rest of the book. Likewise the bio-students will not be overwhelmed by mathematics, but since the objective of the book is to teach quantitative process analysis and process design at a hands-on level some mathematics and model analysis is needed. We hope that the about 100 detailed examples and text notes, together with many instructive problems will be sufficient to illustrate how model analysis is used, also in Bio-reaction Engineering.

• biochemical engineering

• , Department of Chemical and Biochemical E, Technical University of Denmark (DTU), Lyngby, Denmark

  John Villadsen

• , Systems Biology, Chalmers University of Technology, Gothenburg, Sweden

  Jens Nielsen

• , Department of Chemical Engineering, Lund University, Lund, Sweden

  Gunnar Lidén

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