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  • © 2011

Signaling Pathways in Squamous Cancer

  • This book brings together reviews from experts who study mechanisms and signaling pathways that regulate development of squamous cancer in a variety of tissue sites, in both human and experimental mouse models, and to focus on how these specific signaling pathways can be utilized as targets for anti-cancer therapy.

  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xx
  2. Cell Adhesion Molecules in Carcinoma Invasion and Metastasis

    • Barry L. Ziober, Joseph O. Humtsoe, Randall H. Kramer
    Pages 1-19
  3. The Epidermal Growth Factor Receptor in Normal and Neoplastic Epithelia

    • Susan K. Repertinger, Justin G. Madson, Kyle J. Bichsel, Laura A. Hansen
    Pages 113-129
  4. Cyclooxygenase-2 Signaling in Squamous Cell Carcinomas

    • Joyce E. Rundhaug, Susan M. Fischer
    Pages 131-147
  5. Interacting Signaling Pathways in Mouse Skin Tumor Initiation and Progression

    • Christophe Cataisson, Stuart H. Yuspa
    Pages 149-164
  6. NF-κB, IκB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas

    • Antonio Costanzo, Giulia Spallone, Michael Karin
    Pages 201-222
  7. p63 in Squamous Differentiation and Cancer

    • Dennis R. Roop, Maranke I. Koster
    Pages 241-259
  8. Epidermal Growth Factor Receptor-Targeted Therapies

    • Sun M. Ahn, Seungwon Kim, Jennifer R. Grandis
    Pages 305-333
  9. Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies

    • Panomwat Amornphimoltham, Vyomesh Patel, Alfredo Molinolo, J. Silvio Gutkind
    Pages 407-429

About this book

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer.

We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

Editors and Affiliations

  • Center for Molecular Toxicology &, Carcinogenesis, Pennsylvania State University, University Park, USA

    Adam B. Glick

  • National Institute on Deafness &, Other Communication Disorders, National Institute of Health, Bethesda, USA

    Carter Van Waes

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access