Oncofertility

1. Front Matter

   Pages i-xvii

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2. The Science and Technology of Oncofertility

   1. Front Matter

      Pages 1-1

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   2. Reproductive Health After Cancer

      • Clarisa R. Gracia

      Pages 3-9

   3. Designing Follicle–Environment Interactions with Biomaterials

      • Rachel M. Smith, Teresa K. Woodruff, Lonnie D. Shea

      Pages 11-24

   4. Gamete Preservation

      • Susan L. Barrett, Teresa K. Woodruff

      Pages 25-39

   5. To Transplant or Not to Transplant – That Is the Question

      • Sherman J. Silber, Teresa K. Woodruff, Lonnie D. Shea

      Pages 41-54

   6. Clinical Cases in Oncofertility

      • Laxmi A. Kondapalli, Fanzhen Hong, Clarisa R. Gracia

      Pages 55-67

   7. Cancer Genetics: Risks and Mechanisms of Cancer in Women with Inherited Susceptibility to Epithelial Ovarian Cancer

      • Lee P. Shulman, Jeffrey S. Dungan

      Pages 69-85

   8. Protecting and Extending Fertility for Females of Wild and Endangered Mammals

      • Pierre Comizzoli, Nucharin Songsasen, David E. Wildt

      Pages 87-100

3. Historical and Legal Perspectives

   1. Front Matter

      Pages 101-101

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   2. Placing the History of Oncofertility

      • Sarah Rodriguez

      Pages 103-110

   3. Medical Hope, Legal Pitfalls: Potential Legal Issues in the Emerging Field of Oncofertility

      • Gregory Dolin, Dorothy E. Roberts, Lina M. Rodriguez, Teresa K. Woodruff

      Pages 111-134

   4. Domestic and International Surrogacy Laws: Implications for Cancer Survivors

      • Kiran Sreenivas, Lisa Campo-Engelstein

      Pages 135-152

   5. Adoption After Cancer: Adoption Agency Attitudes and Perspectives on the Potential to Parent Post-Cancer

      • Shauna L. Gardino, Andrew E. Russell, Teresa K. Woodruff

      Pages 153-170

4. Clinical and Theoretical Ethics

   1. Front Matter

      Pages 171-171

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   2. Ovarian Tissue Cryopreservation and Bioethical Discourse

      • Cristina L.H. Traina

      Pages 173-180

   3. The Lessons of Oncofertility for Assisted Reproduction

      • Adrienne Asch

      Pages 181-186

   4. Morally Justifying Oncofertility Research

      • Carolyn McLeod

      Pages 187-194

   5. Ethical Dilemmas in Oncofertility: An Exploration of Three Clinical Scenarios

      • Clarisa R. Gracia, Jorge J.E. Gracia, Shasha Chen

      Pages 195-208

   6. Participation in Investigational Fertility Preservation Research: A Feminist Research Ethics Approach

      • Michelle L. McGowan

      Pages 209-221

Oncofertility has emerged as a way to address potential lost or impaired fertility in cancer patients and survivors, with active biomedical research that is developing new ways to help these individuals preserve their ability to have biological children. In order to move beyond oncofertility as a science and medical technology and begin to address the ethical, legal, and social ramifications of this emerging field, we must give voice to scholars from the humanities and social sciences to engage in a multidisciplinary discussion. This book brings together a pool of experts from a variety of fields, including communication, economics, ethics, history, law, religion, and sociology, to examine the complex issues raised by recent developments in oncofertility and to offer advice from national and international perspectives as we create new technology. Given the inherent interdisciplinary nature of oncofertility, this book is not only valuable, but also necessary to cultivate a deep understanding of new issues with the eventual aim of offering proposals for addressing them. Indeed, this book will be useful for people not only within the humanities and social sciences disciplines but also for those who are confronted with cancer and the possibility of impaired fertility and the medical practitioners within oncology and reproductive medicine who are at the front lines of this emerging field.

• Ethical Dilemma
• Moral
• adoption
• bioethics
• ethics
• health
• infertility

From the reviews:

“This is a much-needed book on the multidisciplinary and multifaceted world of oncofertility. … book is appropriate for a wide-ranging audience, from patients to practitioners, researchers to clinicians, students to teachers, in all the fields related to oncofertility. … This book is useful for all who work in any aspect of cancer, infertility, research in these areas, or any area related to fertility preservation.” (Amber R. Cooper, Doody’s Review Service, November, 2010)

• Northwestern University, Feinberg School of Medicine, Chicago, USA

  Teresa K. Woodruff, Laurie Zoloth, Lisa Campo-Engelstein, Sarah Rodriguez

Teresa Woodruff, Ph.D. – Teresa K. Woodruff, Ph.D. is a Thomas J. Watkins Professor of Obstetrics & Gynecology at the Northwestern University Feinberg School of Medicine and Professor of Biochemistry, Molecular Biology and Cell Biology in the Weinberg College of Arts and Sciences. She is the Chief of a newly created Division of Fertility Preservation and the Founder and Director of the Institute for Women’s Health Research. She is the immediate past Director of the Basic Science Programs for the Robert H. Lurie Comprehensive Cancer Center (2000-2007). She is the basic science Associate Editor for Fertility and Sterility (2008-present) and member of several editorial boards including Molecular Cellular Endocrinology, Journal of Molecular Endocrinology and Endocrine Reviews. She serves on the Endocrine Society council (2008-present) and the Society for the Study of Reproduction Board of Directors (2008-present). Her awards include the Distinguished Teaching Award from Northwestern University, the Endocrine Society’s Richard E. Weitzman Memorial Award, The Alumae Award from Northwestern University, and the Distinguished Women in Medicine and Science Award. She was elected a fellow of the American Association for the Advancement of Science in 2005. As a member of the faculty of the Undergraduate Program in Biological Sciences, Dr. Woodruff teaches graduate and undergraduate students in Systems Physiology and the medical student module on female reproduction. She also created the Oncofertility Saturday Academy (OSA) to provide science experiences to high school girls attending the Young Women’s Leadership Charter School (YWLCS). She received her PhD from Northwestern University in 1989. Dr. Woodruff has published more than 100 peer-reviewed papers as well as 40 editorials and book chapters. She is the Principal Investigator on 2 R01 NIH grants, a P01 grant and core facility, and is the PI and director of two NIH funded center grants (The Center forReproductive Research (U54) and the Oncofertility Consortium (UL1). In 2008 she was the recipient of a prestigious W.M. Keck Foundation Medical Research award (2008). The major goals of her laboratory are to identify the mechanisms underlying ovarian follicle development, selection and recruitment and to provide new angles on ovarian disease and fertility conserving options for women. Dr. Woodruff has established a team of oncologists, fertility specialists, social scientists, and education and policy makers to translate her research to the clinical care of women who will lose their fertility due to cancer treatment. She coined the term oncofertility to describe this work, a word that is now officially recognized as a new 'slang' term in the English language. She edited the first book on this topic called Oncofertility (Springer, 2007) where the scope of the problem and current technology, clinical practice tables, procedural guidelines and patient stories are collected. Hallmarks of Woodruff career include a strong focus on ovarian biology, on interdisciplinary approaches to problems and application of the work to the human. Laurie Zoloth, Ph.D. – Laurie Zoloth is a Professor of Medical Humanities, Bioethics, Jewish Studies and Religion. She is also the Director of the Northwestern University Center for Bioethics, Science and Society, and Director of the Brady Program for Ethics and Civic Life, in the Weinberg College of Arts and Sciences. In 2009 she was appointed as the Charles Deering McCormick Professor for Excellence in Teaching. Lisa Campo-Engelstein, Ph.D. – Senior Research Fellow, Oncofertility Consortium and Center for Bioethics, Science and Society Sarah Rodriguez, Ph.D. – Senior Research Fellow, Oncofertility Consortium and Center for Bioethics, Science and Society

Policies and ethics