Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

1. Aging, Control Of Life Span and Expression Of Heat Shock Proteins

   1. Neural Expression Of Small Heat Shock Proteins Influences Longevity And Resistance To Oxidative Stress

      • Robert M. Tanguay, Geneviève Morrow

      Pages 319-336

   2. Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 and DAF-16

      • Ehud Cohen, Andrew Dillin

      Pages 337-348

   3. Protein Quality Control and Heat Shock Gene Expression in the Nervous System

      • Stuart K. Calderwood

      Pages 349-364

   4. Serum Hsp70 Level as a Biomarker of Exceptional Longevity

      • Dellara F. Terry, Alexzander Asea

      Pages 365-370

   5. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

      • N. K. Singh, Preethi Rao, Alexzander Asea

      Pages 371-371

2. Back Matter

   Pages 372-374

   PDF

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

• Chaperones
• HSP
• Nervous System
• Parkinson
• Protein folding
• Stress proteins
• neurons

• Effie and Wofford Cain Centennial Endowed Chair in Clinical Pathology, Chief, Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic and The Texas A&M Health Science Center College of Medicine, Temple, U.S.A

  Alexzander A.A. Asea

• Department of Biological Sciences, Center for the Neurobiology of Stress, University of Toronto at Scarborough, Toronto, Canada

  Ian R. Brown

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