Overview
- First book to comprehensively cover heat shock proteins in cancer -- an area of high interest
- Detailed discussion of the role of hsp90 in cancer therapy and drug development
- Heat shock proteins both as targets for chemotherapy and immunotherapy are examined
- Unique mechanisms for Hsp in cancer such as apoptosis, senescence and a role in NDA repair are discussed
Part of the book series: Heat Shock Proteins (HESP, volume 2)
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Table of contents (19 chapters)
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Back Matter
Keywords
About this book
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Editors and Affiliations
Bibliographic Information
Book Title: Heat Shock Proteins in Cancer
Editors: Stuart K. Calderwood, Michael Y. Sherman, Daniel R. Ciocca
Series Title: Heat Shock Proteins
DOI: https://doi.org/10.1007/978-1-4020-6401-2
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2007
Hardcover ISBN: 978-1-4020-6400-5Published: 21 September 2007
Softcover ISBN: 978-90-481-7627-4Published: 23 November 2010
eBook ISBN: 978-1-4020-6401-2Published: 09 September 2007
Series ISSN: 1877-1246
Series E-ISSN: 1877-1254
Edition Number: 1
Number of Pages: X, 400
Topics: Cancer Research, Immunology, Molecular Medicine
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma