Skip to main content
SpringerLink
Log in
Book cover

Problems of High Altitude Medicine and Biology

  • Conference proceedings
  • © 2007

Overview

Editors:
  1. Almaz Aldashev

    1. Kirghiz Institute of Cardiology, Kyrgyz Republic

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Robert Naeije

    1. Free University of Brussels, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Current research on molecular pathways affected by hypoxic exposure
  • Pathophysiological understanding of the adaptation of the human body to oxygen deprivation
  • High altitude as a public health problem
  • Prevention of high altitude induced or associated diseases
  • Treatment of high altitude illnesses

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (24 papers)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Introduction: 45 Years Of Mountain Medicine

    • James S. Milledge
    Pages 1-9

  3. High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases

    • Dante Penaloza
    Pages 11-37

  4. The Cellular Effects Of Hypoxia In The Pulmonary Circulation

    • Andrew Peacock, Oleg Pak, David Welsh
    Pages 39-55

  5. Angiogenesis And Chronic Hypoxic Pulmonary Hypertension

    • Saadia Eddahibi, Bernadette Raffestin, Serge Adnot
    Pages 57-68

  6. Tetrahydrobiopterin And Pulmonary Hypertension

    • Lan Zhao, Francis Bahaa, Martin Wilkins
    Pages 69-86

  7. Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53

    • T. Ishizaki, S. Mizuno, M. Kadowaki, D. Uesaka, Y. Umeda, M. Morikawa et al.
    Pages 87-99

  8. Pulmonary Adaptation To High Altitude In Wild Mammals

    • Akio Sakai, Ishizaki Takeshi, Koizumi Tomonobu, Matsumoto Takayuki
    Pages 101-117

  9. The Lung At High Altitude: Between Physiology And Pathology

    • Annalisa Cogo, Federica Campigotto, Valter Fasano, Giovanni Grazzi
    Pages 119-131

  10. Sildenafil And Hypoxic Pulmonary Hypertension

    • Baktybek K. Kojonazarov, Mirsaid M. Mirrakhimov, Nicholas W. Morrell, Martin R. Wilkins, Almaz Aldashev
    Pages 133-143

  11. The Role Of Antioxidants In Modulation Of Acclimatization Processes

    • Ashyraly Z. Zurdinov
    Pages 145-150

  12. Gene Polymorphisms And High Altitude Pulmonary Hypertension

    • Almaz Aldashev
    Pages 151-168

  13. Genetic Factors In The Acute Response To Hypoxia In Animals Models

    • Kingman P. Strohl
    Pages 169-184

  14. Who Gets High Altitude Pulmonary Edema And Why?

    • Peter Bärtsch, Christoph Dehnert, Heimo Mairbäurl, Marc Moritz Berger
    Pages 185-195

  15. Effects Of Inhaled Nitric Oxide And Oxygen In High Altitude Pulmonary Edema

    • Inder S. Anand
    Pages 197-209

  16. Altered Autoregulation Of Cerebral Blood Flow In Hypoxia: Relevance To The Pathophysiology Of Acute Mountain Sickness

    • Robert Naeije, Aurelie van Osta
    Pages 211-220

  17. Cardiac Limitation To Exercise Capacity At High Altitudes

    • Sandrine Huez, Robert Naeije, Vitalie Faoro
    Pages 221-229

  18. Pediatric High Altitude Heart Disease: A Hypoxic Pulmonary Hypertension Syndrome

    • Tianyi Wu
    Pages 231-247

  19. Clinical And Functional Features Of Chronic Obstructive Pulmonary Disease In The Highlanders Of Kyrgzstan

    • T. M. Sooronbaev, S. B. Shabykeeva, A. K. Mirzaachmatova, G. K. Kadyraliev, Mirsaid M. Mirrakhimov
    Pages 249-257

  20. Monitoring The Morphological And Functional Parameters Of Platelets In Patients With Thrombocytopenic Purpura During High Mountain Treatment

    • Abdukhalim R. Raimjanov, Irina Tsopova, Svetlana Astapova
    Pages 259-262
Back to top

Keywords

About this book

The major characteristic pathological findings of pulmonary vascular remodelling are increased wall thickening of pulmonary vessels and mus- larization of small arteries. In laboratory animals, decreased ambient oxygen concentrations cause similar pathological findings, including pulmonary smooth muscle hypertrophy and proliferation [22,23]. It has been suggested that proliferation of pulmonary arterial smooth muscle cells (PASMC) is a key component of pulmonary vascular remodelling, and several in vitro studies have also addressed that exposure to hypoxia can stimulate prolife- tion of PASMC [13,4,1]. The proliferation of the PASMC begins when the cells enter into the cell cycle. The most important molecular event necessary for the progress of the cell cycle is phosphorylation of retinoblastoma protein by cyclin-dependent kinase (CDK)-cyclin complexes. The CDK activity can be inhibited by CDK inhibitors and the expression of CDK inhibitor is a major regulator of the transition between each phase of the cell cycle [7]. Previous studies have noted that CDK inhibitor p27 plays an important role in the inhibition of the CDK activity and proliferation in vascular smooth muscle cells [2,3]. The G1 phase in severe hypoxia is suggested to involve the CKI p27, because the expression of p27 increased in several cell-lines when they were exposed to extreme hypoxia [20,5]. Previous reports indicate that hypoxia decreases the p27 expression in the murine lung [23,24] and we found that PGI2 suppresses hypox- induced proliferation of PASMC and maintains p27 in PASMC [20].

Editors and Affiliations

  • Kirghiz Institute of Cardiology, Kyrgyz Republic

    Almaz Aldashev

  • Free University of Brussels, Belgium

    Robert Naeije

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation