Animals and Alternatives in Toxicology

This volume considers the second report of the FRAME Toxicity Committee presenting reviews and discussions by invited authors and general discussions. It covers developments in toxicology and the use of non-animal methods in toxicity testing since the first report, published in 1983; it highlights the need for rationalisation and harmonisation of regulatory guidelines for more critical attitudes toward currently accepted animal tests and for more attention to be focussed on non-animal alternatives; how to inform scientists of alternatives to animals; and how to develop and integrate non-animal alternatives. The book is a key document in the development, validation, and use of non-animal methods and is aimed at toxicologists, pharmacologists, and policy-makers in academia, industry and government.