An up-to-date basic introduction to the blood-brain barrier which starts with a clear description of the key historical experiments which have led to the concept of this multi-faceted barrier mechanism. There are sections on the morphology of the barrier, basic transport kinetics and carrier-meditated processes. Subsequent chapters deal with transport of glucose and amino-acids, peptides and nucleotides. The final chapter reviews various models of neurological disorders which can be used to unravel the complexity of the barrier in health and disease.
central nervous system kinetics morphology research
Authors and affiliations
Malcolm B. Segal
1.Sherrington School of Physiology UMDSGuy’s and St Thomas’s HospitalsLondonUK