Advertisement

High Resolution EPR

Applications to Metalloenzymes and Metals in Medicine

  • Lawrence Berliner
  • Graeme  Hanson

Part of the Biological Magnetic Resonance book series (BIMR, volume 28)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. John R. Pilbrow
    Pages 1-10
  3. High-Resolution EPR Methods

  4. Iron Proteins

    1. Front Matter
      Pages 231-231
    2. Betty J. Gaffney
      Pages 233-268
    3. Nataša Mitić, Gerhard Schenk, Graeme R Hanson
      Pages 269-395
    4. Benjamin P. Luchsinger, Eric D. Walter, Lisa J. Lee, Jonathan S. Stamler, David J. Singel
      Pages 419-438
  5. Nickel and Copper Enzymes

    1. Front Matter
      Pages 439-439
    2. Maurice van Gastel, Wolfgang Lubitz
      Pages 441-470
  6. Metals in Medicine

    1. Front Matter
      Pages 505-505
    2. Aviva Levina, Rachel Codd, Peter A. Lay
      Pages 551-579
    3. Arnold M. Raitsimring, Andrei V. Astashkin, Peter Caravan
      Pages 581-621
  7. Back Matter
    Pages 1-43

About this book

Introduction

High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine

Prof. Graeme Hanson, University of Queensland and Prof. Lawrence Berliner, University of Denver

Metalloproteins are involved in a variety of biologically important processes, including metal ion and oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis and peptide hydrolysis, environmental oxygen, sulphur, and nitrogen cycles, and disease states. High-resolution EPR spectroscopy is crucial in determining the geometric and electronic structural characterization of the redox cofactors in metalloenzymes, which is essential for understanding their reactivity in complex biological systems.

This volume, Part I of a two-volume set, covers high-resolution EPR methods, computer simulation, density functional theory, and their application to iron proteins, nickel, and copper enzymes and metals in medicine. The following chapters, written by experts in their fields, include:

Advanced Pulse EPR Methods for the Characterization of Metalloproteins: Jeffrey Harmer, George Mitrikas, and Arthur Schweiger

Probing Structural and Electronic Parameters in Randomly Oriented Metalloproteins by Orientation-Selective ENDOR Spectroscopy: Reinhard Kappl, Gerhard Bracic, and Jürgen Hüttermann

Molecular Sophe: An Integrated Approach to the Structural Characterization of Metalloproteins: The Next Generation of Computer Simulation Software: Graeme Hanson, Christopher Noble, and Simon Benson

Spin-Hamiltonian Parameters from First Principle Calculations: Theory and Application: Frank Neese

EPR of Mononuclear Non-Heme Iron Proteins: Betty Gaffney

Binuclear Non-Heme Iron Enzymes: Nataša Mitic, Gerhard Schenk, and Graeme Hanson

Probing the Structure–Function Relationship of Heme Proteins Using Multifrequency Pulse EPR Techniques: Sabine Van Doorslaer

EPR Studies of the Chemical Dynamics of NO and Hemoglobin Interactions: Benjamin Luchsinger, Eric Walter, Lisa Lee, Jonathan Stamler, and David Singel

EPR Investigation of [NiFe] Hydrogenases: Maurice van Gastel and Wolfgang Lubitz

Unique Spectroscopic Features and Electronic Structures of Copper Proteins: Relation to Reactivity: Jungjoo Yoon and Edward Solomon

Insulin-Enhancing Vanadium Pharmaceuticals: The Role of Electron Paramagnetic Resonance Methods in the Evaluation of Antidiabetic Potential: Barry Liboiron

Chromium in Cancer and Dietary Supplements: Aviva Levina, Rachel Codd, and Peter Lay

High-Frequency EPR and ENDOR Characterization of MRI Contrast Agents: Arnold Raitsimring, Andrei Astashkin, and Peter Caravan

Keywords

X-ray chemistry dynamics magnetic resonance medicine proteins spectroscopy

Editors and affiliations

  • Lawrence Berliner
  • Graeme  Hanson

There are no affiliations available

Bibliographic information

Industry Sectors
Pharma
Biotechnology
Consumer Packaged Goods