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West Nile Encephalitis Virus Infection

Viral Pathogenesis and the Host Immune Response

  • Book
  • © 2009

Overview

Authors:
  1. Michael S. Diamond

    1. Departments of Medicine, Molecular Microbiology, Pathology & Immunology Washington University School of Medicine, St. Louis, USA

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  • An in-depth look at an emerging threat to human health and safety
  • An up-to-date compilation of current research on West Nile virus pathogenesis and immune response
  • Contributions prepared by an internationally-renowned group of researchers
  • Includes supplementary material: sn.pub/extras

Part of the book series: Emerging Infectious Diseases of the 21st Century (EIDC)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xix
    Download chapter PDF

  2. Global Epidemiology of West Nile Virus

    • Lyle R. Petersen
    Pages 1-23

  3. West Nile Virus: Molecular Epidemiology and Diversity

    • Gregory D. Ebel, Laura D. Kramer
    Pages 25-43

  4. Vector Biology and West Nile Virus

    • Carol D. Blair
    Pages 45-67

  5. Clinical Manifestations of Neurological Disease

    • J. David Beckham, Kenneth L. Tyler
    Pages 69-95

  6. Molecular Biology of West Nile Virus

    • Margo A. Brinton
    Pages 97-136

  7. Virulence of West Nile Virus in Different Animal Hosts

    • David W. C. Beasley, Alan D. T. Barrett
    Pages 137-153

  8. Innate immune Response and Mechanisms of Interferon Antagonism Against West Nile Virus

    • Jared D. Evans, Christoph Seeger
    Pages 155-168

  9. Innate Immune Responses to West Nile Virus Infection

    • Alvaro Arjona, Erol Fikrig
    Pages 169-187

  10. Mechanisms of Complement Regulation of Infection by Flaviviruses

    • Erin Mehlhop, Michael S. Diamond
    Pages 189-217

  11. Antibody-Mediated Neutralization of West Nile Virus: Factors that Govern Neutralization Potency

    • Christiane A. Jost, Theodore C. Pierson
    Pages 219-247

  12. Structural Basis of Antibody Protection Against West Nile Virus

    • Richard J. Kuhn
    Pages 249-264

  13. Molecular Mechanisms of Flaviviral Membrane Fusion

    • Yorgo Modis, Vinod Nayak
    Pages 265-286

  14. CD4 + and CD8 + T-Cell Immune Responses in West Nile Virus Infection

    • Mario Lobigs, Arno Müllbacher, Matthias Regner
    Pages 287-307

  15. Enhanced Antigen Processing or Immune Evasion? West Nile Virus and the Induction of Immune Recognition Molecules

    • Nicholas J. C. King, Ariane Davison, Daniel R. Getts, David Ping Lu, Meghann Teague Getts, Amanda Yeung et al.
    Pages 309-339

  16. Chemokines and Clearance of West Nile Virus Infection

    • Robyn S. Klein
    Pages 341-359

  17. Persistence of West Nile Virus Infection in Vertebrates

    • Robert B. Tesh, Shu-Yuan Xiao
    Pages 361-377

  18. West Nile Virus Infection of the Central Nervous System

    • Melanie A. Samuel, Michael S. Diamond
    Pages 379-399

  19. The Human Antibody Response Against WNV

    • Mark Throsby, Jaap Goudsmit, John de Kruif
    Pages 401-416

  20. Antibody Protection and Therapy for West Nile Virus Infections

    • John T. Roehrig
    Pages 417-425
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Keywords

About this book

West Nile virus is a neurotropic flavivirus that has emerged globally as a primary cause of viral encephalitis. Infection of humans and other vertebrate animals is associated with a febrile illness that can progress to a lethal encephalitis or flaccid paralysis syndrome. Its appearance in the Western Hemisphere in 1999 and the corresponding increase in global disease burden over the last decade have been accompanied by intensive study, including the entry of many scientists into the field. Breakthroughs have been made in understanding the unique transmission pattern between the vector and the multiple avian and mammalian hosts and targets. Studies in mammalian systems have dissected the viral and host factors that determine the pathogenesis and outcome of West Nile virus infection. On the basis of these experiments, progress has been made on the identification of genetic factors that predispose to severe human disease. Thus, in a remarkably short period of time, insight has been gained on a wide variety of disciplines related to West Nile virus biology. The aim of this book was to assemble an up-to-date and cutti- edge anthology from the leading experts in the field. The chapters are balanced by submissions from newcomers who have made significant recent contributions with those from established investigators who have dedicated their careers to the study of West Nile virus.

Authors and Affiliations

  • Departments of Medicine, Molecular Microbiology, Pathology & Immunology Washington University School of Medicine, St. Louis, USA

    Michael S. Diamond

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