Cigarette Smoke and Oxidative Stress

1. Front Matter

   Pages I-XI

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2. Oxidative Stress

   • Barry B. Halliwell, Henrik E. Poulsen

   Pages 1-4

3. Tobacco Smoke Constituents Affecting Oxidative Stress

   • Jan B. Wooten, Salem Chouchane, Thomas E. McGrath

   Pages 5-46

4. Oxidative Modifications of Proteins and Lipids by Cigarette Smoke (CS). A Central Role for Unsaturated Aldehydes in CS-Mediated Airway Inflammation

   • Albert van der Vliet

   Pages 47-73

5. Cigarette Smoke-Induced Redox Signaling and Gene Expression in In Vitro and In Vivo Models

   • Thomas Müller, Stephan Gebel

   Pages 75-111

6. Redox Effects of Cigarette Smoke in Lung Inflammation

   • Irfan Rahman

   Pages 113-164

7. Oxidative Stress in the Pathogenesis of Chronic Obstructive Pulmonary Disease

   • Irfan Rahman

   Pages 165-197

8. Modulation of Cigarette Smoke Effects by Diet and Antioxidants

   • Marion Dietrich, Gladys Block

   Pages 199-213

9. Modulation of Cigarette Smoke Effects by Antioxidants: Oxidative Stress and Degenerative Diseases

   • Jari Kaikkonen, Jukka T. Salonen

   Pages 215-235

10. Smoking Depletes Vitamin C: Should Smokers Be Recommended to Take Supplements?

    • Jens Lykkesfeldt

    Pages 237-260

11. Experimental In Vitro Exposure Methods for Studying the Effects of Inhalable Compounds

    • Michaela Aufderheide

    Pages 261-277

12. Oxidative Stress in Laboratory Animals Exposed to Cigarette Smoke, with Special Reference to Chronic Obstructive Pulmonary Disease

    • Chris Coggins

    Pages 279-291

13. Pulmonary Effects of Cigarette Smoke in Humans

    • Nick H. T. ten Hacken, Dirkje S. Postma

    Pages 293-338

14. Smoking and Oxidative Stress: Vascular Damage

    • Thomas Münzel, Felix Post, Ascan Warnholtz

    Pages 339-364

15. Nrf2: a Transcription Factor that Modifies Susceptibility to Cigarette Smoke-Induced Pulmonary Oxidative Stress and Emphysema

    • Shyam Biswal, Thomas W. Kensler

    Pages 365-377

16. Tobacco Smoke and Skin Aging

    • Akimichi Morita

    Pages 379-385

17. Cigarette Smoke and Oxidative DNA Modification

    • Henrik E. Poulsen, Allan Weimann, Barry B. Halliwell

    Pages 387-402

18. Back Matter

    Pages 403-407

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From a public health point of view, there is little doubt that one of the most important preventable causes of disease worldwide is tobacco smoking. It is also clear that tobacco smoke contains a vast number of chemicals with important biological efects in disease processes. Te gas phase of tobacco smoke is oxidizing, the tar phase is reducing, and whole smoke is roughly neutral, so its efects on oxidative stress may be an “antioxidant paradox. ” From a scientifc point of view, we found it of interest to make a comprehensive ov- view of what we presently know about oxidative stress and tobacco smoke, because sm- ing is presently the best-known common condition associated with oxidative stress, and it may serve as a model for others. To this end, we have asked distinguished researchers from the public and the private sectors to evaluate the present scientifc status in their particular area. Authors were selected purely because of their scientifc merits. We do not claim that all the well-described health hazards associated with cigarette smoking stem from oxidative stress, nor should we. However, we ought to be able to fnd out, and for some of those health hazards, we can already say. We hope this book will stimulate more research to fnd answers to the remaining questions. Barry Halliwell and Henrik E. Poulsen Contents 1 Oxidative Stress . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Barry B. Halliwell and Henrik E. Poulsen 2 Tobacco Smoke Constituents Affecting Oxidative Stress . . . . . . . . . . .

• Biology Biochemistry
• Cardiovascular Disease
• Cellular Signalling
• Free Radical Chemistry
• Pathogenesis on Inlammatory Diseases
• aging
• biochemistry

• Pharmacology Group, University of London King’s College, London, UK

  Barry B. Halliwell

• Dept. of Clinical Pharmalogy, Rigshospitalet, University Hospital Copenhagen, Copenhagen N, Denmark

  Henrik E. Poulsen

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