© 2005

Interstitial Fibrosis in Heart Failure

  • Francisco J. Villarreal

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 253)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Architecture of the Normal and Remodeled Heart

    1. Bodh I. Jugdutt
      Pages 23-55
    2. R. Dale Brown, M. Darren Mitchell, Carlin S. Long
      Pages 57-81
    3. Sara A. Epperson, Åsa B. Gustafsson, Annette M. Gonzalez, Sonia Villegas, J. Gary Meszaros, Laurence L. Brunton
      Pages 83-97
  3. Diagnostic Tools for the Identification of Myocardial Fibrosis and Changes in Ventricular Mechanics

    1. Mark R. Holland, Samuel A. Wickline
      Pages 115-148
    2. Robert C. Gorman, Benjamin M. Jackson, Joseph H. Gorman, L. Henry Edmunds Jr.
      Pages 149-163
  4. Pathophysiology of Cardiac Remodeling and Fibrosis

    1. English Chapman, Francis G. Spinale
      Pages 181-196
    2. Joseph S. Janicki, Gregory L. Brower, Amanda L. Chancey, Mary F. Forman, Lynetta J. Jobe
      Pages 197-209
  5. Matrix Metalloproteinasses in Cardiac Remodeling

    1. Manoj M. Lalu, Hernando Leon, Richard Schulz
      Pages 213-237
    2. Baljit S. Walia, Stephen C. Jones, Jianming Hao, Ian M. C. Dixon
      Pages 253-271
  6. Prospect for Therapy of the Fibrosed Heart

    1. Lindsay Brown, Vincent Chan, Andrew Fenning
      Pages 275-310
    2. Ramareddy V. Guntaka, Karl T. Weber
      Pages 329-341
    3. Suresh C. Tyagi
      Pages 355-363
  7. Back Matter
    Pages 365-373

About this book


Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis.

This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.


gene therapy heart heart failure myocardial infarction physiology

Editors and affiliations

  • Francisco J. Villarreal
    • 1
  1. 1.Department of MedicineUniversity of California, San Diego School of MedicineSan DiegoUSA

About the editors

Francisco J. Villarreal, M.D., Ph.D. is a Professor in the Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California.

Bibliographic information

  • Book Title Interstitial Fibrosis in Heart Failure
  • Editors Francisco Villarreal
  • Series Title Developments in Cardiovascular Medicine
  • DOI
  • Copyright Information Springer Science + Business Media, Inc. 2005
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-0-387-22824-2
  • Softcover ISBN 978-1-4419-1983-0
  • eBook ISBN 978-0-387-22825-9
  • Series ISSN 0166-9842
  • Edition Number 1
  • Number of Pages XIV, 373
  • Number of Illustrations 93 b/w illustrations, 0 illustrations in colour
  • Topics Cardiology
    Cardiac Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology