Design and Analysis of DNA Microarray Investigations

  • Richard M. Simon
  • Edward L. Korn
  • Lisa M. McShane
  • Michael D. Radmacher
  • George W. Wright
  • Yingdong Zhao

Part of the Statistics for Biology and Health book series (SBH)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pages 1-4
  3. Pages 29-38
  4. Pages 39-52
  5. Pages 53-64
  6. Pages 65-94
  7. Pages 95-119
  8. Pages 121-155
  9. Back Matter
    Pages 157-199

About this book


This book is targeted to biologists with limited statistical background and to statisticians and computer scientists interested in being effective collaborators on multi-disciplinary DNA microarray projects. State-of-the-art analysis methods are presented with minimal mathematical notation and a focus on concepts. This book is unique because it is authored by statisticians at the National Cancer Institute who are actively involved in the application of microarray technology.

Many laboratories are not equipped to effectively design and analyze studies that take advantage of the promise of microarrays. Many of the software packages available to biologists were developed without involvement of statisticians experienced in such studies and contain tools that may not be optimal for particular applications. This book provides a sound preparation for designing microarray studies that have clear objectives, and for selecting analysis tools and strategies that provide clear and valid answers. The book offers an in depth understanding of the design and analysis of experiments utilizing microarrays and should benefit scientists regardless of what software packages they prefer. In order to provide all readers with hands on experience in data analysis, it includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is freely available from the National Cancer Institute for non-commercial use.

The authors are current or former members of the Biometric Research Branch at the National Cancer Institute.  They have collaborated on major biomedical studies utilizing microarrays and in the development of statistical methodology for the design and analysis of microarray investigations. Dr. Simon, chief of the branch, is also the architect of BRB-ArrayTools.


DNA Microarray Radiologieinformationssystem data analysis gene expression image analysis

Authors and affiliations

  • Richard M. Simon
    • 1
  • Edward L. Korn
    • 1
  • Lisa M. McShane
    • 1
  • Michael D. Radmacher
    • 2
    • 3
  • George W. Wright
    • 1
  • Yingdong Zhao
    • 1
  1. 1.Biometric Research BranchNational Cancer InstituteBethesda
  2. 2.Department of MathematicsKenyon CollegeGambier
  3. 3.Department of BiologyKenyon CollegeGambier

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag New York, Inc. 2003
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-387-00135-7
  • Online ISBN 978-0-387-21866-3
  • Series Print ISSN 1431-8776
  • Buy this book on publisher's site
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