Cancer Precursors

Epidemiology, Detection, and Prevention

  • Eduardo L. Franco
  • Thomas E. Rohan

Table of contents

  1. Front Matter
    Pages i-xx
  2. Site-Specific Precancerous Conditions

    1. Thomas E. Rohan, Eduardo L. Franco
      Pages 1-3
  3. Biological Basis of Carcinogenesis

    1. Front Matter
      Pages 5-5
    2. Michael B. Cohen
      Pages 20-29
  4. Issues Related to Measurement and Interpretation of Cancer Precursors

  5. Site-Specific Precancerous Conditions

    1. Front Matter
      Pages 75-75
    2. R. Sankaranarayanan, Thara Somanathan
      Pages 77-95
    3. Thomas L. Vaughan
      Pages 96-116
    4. Pelayo Correa
      Pages 117-126
    5. John A. Baron
      Pages 127-150
    6. Joel M. Palefsky
      Pages 151-163
    7. Morris Sherman, Ian Wanless
      Pages 164-185
    8. Ralph H. Hruban, Christine Iacobuzio-Donahue, Michael Goggins
      Pages 186-200
    9. Pamela M. Marcus, William D. Travis
      Pages 201-219
    10. Richard P. Gallagher, Tim K. Lee
      Pages 220-231
    11. Thomas E. Rohan, Rita A. Kandel
      Pages 232-248
    12. Eduardo L. Franco, Alex Ferenczy
      Pages 249-286
    13. Eduardo L. Franco, Alex Ferenczy
      Pages 287-303
    14. Joellen M. Schildkraut
      Pages 304-320
    15. Margaret M. Madeleine, Janet R. Daling, Hisham K. Tamimi
      Pages 321-332
    16. James R. Marshall, David P. Wood Jr.
      Pages 333-343
    17. Kamal S. Pohar, Carlos Cordon-Cardo
      Pages 344-361
  6. Control of Cancer Precursors

    1. Front Matter
      Pages 363-363
    2. Anthony B. Miller
      Pages 365-373
    3. Gary J. Kelloff, Caroline C. Sigman
      Pages 374-388
    4. Eduardo L. Franco, Thomas E. Rohan
      Pages 389-403
  7. Conclusion

    1. Front Matter
      Pages 405-405
    2. Thomas E. Rohan, Eduardo L. Franco
      Pages 407-410
  8. Back Matter
    Pages 411-430

About this book


Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process.


Cancer precursors cancer chemoprevention detection epidemiological epidemiology molecular epidemiology prevention prevention strategies screening

Editors and affiliations

  • Eduardo L. Franco
    • 1
    • 2
  • Thomas E. Rohan
    • 3
  1. 1.Departments of Oncology and EpidemiologyMcGill UniversityMontrealCanada
  2. 2.Division of Cancer EpidemiologyMcGill UniversityMontrealCanada
  3. 3.Department of Epidemiology and Social MedicineAlbert Einstein College of MedicineBronxUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology