Zinc Finger Proteins

From Atomic Contact to Cellular Function

  • Shiro Iuchi
  • Natalie Kuldell

Part of the Molecular Biology Intelligence Unit book series (MBIU)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account

  3. Binding of Zinc Fingers to DNA

    1. Raymond S. Brown, Jane Flint
      Pages 14-19
    2. G. Marius Clore, James G. Omichinski
      Pages 20-25
    3. Ryoji Masui, Noriko Nakagawa, Seiki Kuramitsu
      Pages 31-34
    4. Patrick Van Roey, Marlene Belfort, Victoria Derbyshire
      Pages 35-38
    5. Jay S. Hanas, Jason L. Larabee, James R. Hocker
      Pages 39-46
    6. Nicoletta Corbi, Valentina Libri, Claudio Passananti
      Pages 47-55
  4. Binding of Zinc Fingers to RNA

    1. Paul J. Romaniuk
      Pages 56-65
    2. Martyn K. Darby
      Pages 66-75
    3. Cristina Mendez-Vidal, Fredrik Hellborg, Margareta T. Wilhelm, Magdalena Tarkowska, Klas G. Wiman
      Pages 76-79
    4. Perry J. Blackshear, Ruth S. Phillips, Wi S. Lai
      Pages 80-90
    5. John Dresios, Yuen-Ling Chan, Ira G. Wool
      Pages 91-98
  5. Binding of Zinc Fingers to Proteins

    1. Algirdas Velyvis, Jun Qin
      Pages 99-105
    2. Roberto N. De Guzman, Maria A. Martinez-Yamout, H. Jane Dyson, Peter E. Wright
      Pages 114-120
    3. Odile Filhol, Maria José Benitez, Claude Cochet
      Pages 121-127
  6. Binding of Zinc Fingers to Small Molecules

  7. Common Domains Present in Zinc Finger Proteins

    1. Gilbert G. Privé, Ari Melnick, K. Farid Ahmad, Jonathan D. Licht
      Pages 134-150
  8. Biology of Zinc Finger Proteins

    1. Dimitri Krainc
      Pages 168-173
    2. Sean Bong Lee, Hongjie Li, Ho-Shik Kim
      Pages 174-181
    3. Huifei Liu, Yang Shi
      Pages 182-194
    4. Natalie Kuldell
      Pages 195-199
    5. Pablo Gómez-del Arco, Taku Naito, John Seavitt, Toshimi Yoshida, Christine Williams, Katia Georgopoulos
      Pages 200-206
    6. Carl E. Allen, Lai-Chu Wu
      Pages 213-220
    7. Marc Haenlin, Lucas Waltzer
      Pages 221-231
    8. Federica Piccioni, Charlotte J. Sumner, Kenneth H. Fischbeck
      Pages 232-238
    9. Takahisa Ikegami, Masahiro Shirakawa
      Pages 239-246
    10. Liqing Wu, Carl G. Maki
      Pages 252-260
  9. Biology of Zinc Ion

    1. David J. Eide
      Pages 261-264
    2. Kirsteen H. Maclean
      Pages 265-271
  10. Back Matter
    Pages 273-276

About this book


In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.


DNA RNA gene expression genes protein family proteins ribosomal RNA signal transduction transcription

Editors and affiliations

  • Shiro Iuchi
    • 1
  • Natalie Kuldell
    • 2
  1. 1.Department of Cell BiologyHarvard Medical SchoolBostonUSA
  2. 2.Biological Engineering DivisionMassachusetts Institute of TechnologyCambridgeUSA

Bibliographic information

  • DOI
  • Copyright Information Landes Bioscience / and Kluwer Academic / Plenum Publishers 2005
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-306-48229-8
  • Online ISBN 978-0-387-27421-8
  • Buy this book on publisher's site
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