Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

  • Hidezo Mori
  • Hikaru Matsuda

Table of contents

  1. Front Matter
    Pages I-X
  2. Vascular Precursor Cells and Their Potentiation

    1. Front Matter
      Pages 1-1
    2. Hideki Iwaguro, Takayuki Asahara
      Pages 3-15
    3. Noritoshi Nagaya, Naoto Fukuyama, Yasuhiko Tabata, Hidezo Mori
      Pages 17-30
    4. Shinji Tomita, Takeshi Nakatani
      Pages 31-42
  3. Development of Myocardial Sheets and Their Cell Sources

    1. Front Matter
      Pages 43-43
    2. Tatsuya Shimizu, Hidekazu Sekine, Yuki Isoi, Masayuki Yamato, Akihiko Kikuchi, Teruo Okano
      Pages 45-52
  4. Hybrid Tissues

    1. Front Matter
      Pages 81-81
    2. Toshia Fujisato, Kenji Minatoya, Sachiko Yamazaki, Yin Meng, Kazuo Niwaya, Akio Kishida et al.
      Pages 83-94
    3. Hatsue Ishibashi-Ueda, Yasuhide Nakayama
      Pages 95-104
    4. Goki Matsumura, Toshiharu Shin’oka
      Pages 105-113
  5. New Aspects of Angiogenesis

    1. Front Matter
      Pages 115-115
    2. Akira Marui, Kazuhiko Doi, Keiichi Tambara, Yutaka Sakakibara, Koji Ueyama, Atsushi Iwakura et al.
      Pages 145-156
    3. Yoshiaki Takewa, Yukitoshi Shirakawa, Yoshiyuki Taenaka, Eisuke Tatsumi, Yoshiki Sawa, Hikaru Matsuda et al.
      Pages 157-172
  6. Clinical Results of Therapeutic Angiogenesis and Vasculogenesis

    1. Front Matter
      Pages 181-181
    2. Yousuke Katsuda, Yoshiaki Takeshita, Ken Arima, Yutaka Saitoh, Tsutomu Imaizumi, Takayuki Asahara et al.
      Pages 183-189
    3. Yousuke Katsuda, Yoshiaki Takeshita, Ken Arima, Yutaka Saitoh, Ken-ichiro Sasaki, Shinichi Shintani et al.
      Pages 213-220
    4. Kazuteru Fujimoto, Hiroo Miyagi, Yuji Miyao, Ichiro Kajiwara, Youko Oe, Fumio Kawano et al.
      Pages 221-225
    5. Masakatsu Ohtani, Toshihiro Soma, Akihiko Taguchi
      Pages 227-233
  7. Back Matter
    Pages 235-238

About this book


The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re­ pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap­ proaches. Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome-005, RHGTEFB-saisei-003, and CRCD-junkanki-009) and a grant from NEDO of Japan, that significant progress has been possible.


Transplantat angiogenesis angiography bone marrow cardiovascular cardiovascular system gene therapy heart surgery tissue engineering transplantation vascular disease

Editors and affiliations

  • Hidezo Mori
    • 1
  • Hikaru Matsuda
    • 2
  1. 1.Department of Cardiac PhysiologyNational Cardiovascular Center Research InstituteSuita, OsakaJapan
  2. 2.Division of Cardiovascular Surgery, Department of SurgeryOsaka University Graduate School of MedicineSuita, OsakaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Tokyo 2005
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-23925-3
  • Online ISBN 978-4-431-27378-3
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology