Molecular Analysis of B Lymphocyte Development and Activation

  • Harinder Singh
  • Rudolf Grosschedl

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 290)

Table of contents

  1. Front Matter
    Pages I-XI
  2. D. G. Schatz, E. Spanopoulou
    Pages 49-85
  3. L. M. Corcoran
    Pages 105-146
  4. G. Drozina, J. Kohoutek, N. Jabrane-Ferrat, B. M. Peterlin
    Pages 147-170
  5. A. Timm, R. Grosschedl
    Pages 225-252
  6. Back Matter
    Pages 253-258

About this book


The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.


B cell receptor DNA-binding proteins biochemistry cell class switch recombination cytokine cytokine receptors gene genes immunoglobulin protein proteins transcriptional regulators

Editors and affiliations

  • Harinder Singh
    • 1
  • Rudolf Grosschedl
    • 2
  1. 1.Department of Molecular Genetics and Cell Biology Howard Hughes Medical InstituteThe University of ChicagoChicagoUSA
  2. 2.Department of Cellular and Molecular ImmunologyMax-Plank-Institute of ImmunobiologyFreiburgGermany

Bibliographic information

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