Regulatory T Cells in Inflammation

  • Leonie S. Taams
  • Marca H. M. Wauben
  • Arne N. Akbar

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Origin, function and distribution of regulatory T cells

  3. The potential use of regulatory T cells in immunotherapy

    1. Nadia Giarratana, Giuseppe Penna, Silvia Gregori, Kenn C. Daniel, Luciano Adorini
      Pages 95-109
    2. Sophie Candon, Lucienne Chatenoud
      Pages 111-132
    3. Clare Baecher-Allan, Vissia Viglietta, David A. Hafler
      Pages 133-151
    4. Jocea M. van Amelsfort, Johannes W. J. Bijlsma, Leonie S. Taams
      Pages 153-172
    5. Katie E. Birch, Milica Vukmanovic-Stejic, John R. Reed, Malcolm H.A. Rustin, Arne N. Akbarl
      Pages 205-219
  4. Back Matter
    Pages 237-240

About this book


Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent.

Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.


Activation Antigen Diabetes T cell development diseases genes immune response immune system immunity immunotherapy inflammation regulation research transplantation

Editors and affiliations

  • Leonie S. Taams
    • 1
  • Marca H. M. Wauben
    • 2
  • Arne N. Akbar
    • 3
  1. 1.Infection & Immunity Research Group, Franklin-Wilkins BuildingKing's College LondonLondonUK
  2. 2.Department of Immunohematology and Blood TransfusionE3-Q, Leiden University Medical CenterLeidenThe Netherlands
  3. 3.Department of Immunology and Molecular Pathology, Division of Infection and ImmunityUniversity College LondonLondonUK

Bibliographic information

Industry Sectors
Health & Hospitals