Table of contents

  1. Front Matter
  2. George G. Wu, Mingsheng Huang
    Pages 1-35
  3. David L. Hughes
    Pages 37-61
  4. Kenzo Sumi, Hidenori Kumobayashi
    Pages 63-95
  5. Albert J. DelMonte, Eric D. Dowdy, Daniel J. Watson
    Pages 97-122
  6. Jay F. Larrow, Eric N. Jacobsen
    Pages 123-152
  7. Steven J. Mehrman, Ahmed F. Abdel-Magid, Cynthia A. Maryanoff, Bart P. Medaer
    Pages 153-180
  8. Jeffrey T. Bien, Gregory C. Lane, Matthew R. Oberholzer
    Pages 263-283

About this book


The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.


Alkene Inorganic Chemistry Organometallic Synthesis Organometallic chemistry Pharmaceutical Chemistry Process Chemistry chemistry metals organic chemistry pharmaceuticals

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-01603-8
  • Online ISBN 978-3-540-36966-0
  • Series Print ISSN 1436-6002
  • Series Online ISSN 1616-8534
  • Buy this book on publisher's site
Industry Sectors
Chemical Manufacturing