Cancer Gene Therapy

Past Achievements and Future Challenges

  • Nagy A. Habib

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 465)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Clinical Problem

    1. Susan J. Cleator, Pat Price
      Pages 3-10
  3. Vectors

    1. Prem Seth
      Pages 13-22
    2. Yasuhiro Takeuchi, Massimo Pizzato
      Pages 23-35
    3. Paul L. Hallenbeck, Susan C. Stevenson
      Pages 37-46
    4. David Bermudes, Brooks Low, John Pawelek
      Pages 57-63
    5. Nina Krauzewicz, Beverly E. Griffin
      Pages 73-82
    6. Leila Zarif, Raphael J. Mannino
      Pages 83-93
    7. Stephen Coe, Michael Harron, Marc Winslet, Geoffrey Goldspink
      Pages 95-111
  4. Cell Cycle Control

    1. Yaw Ohene-Abuakwa, Massimo Pignatelli
      Pages 115-126
    2. Vivien J. Tannoch, Phil W. Hinds, Li-Huei Tsai
      Pages 127-140
  5. Apoptosis

    1. Alexandra Pietersen, Mathieu H. M. Noteborn
      Pages 153-161
    2. Anu-Maaria Sandmair, Matti Vapalahti, Seppo Ylä-Herttuala
      Pages 163-170
  6. Tumout Suppressor Genes

    1. Ragai R. Mitry, Marc R. Mansour, Roman Havlik, Nagy A. Habib
      Pages 193-205
    2. Junzo Kigawa, Naoki Terakawa
      Pages 207-214

About this book

Introduction

With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

Keywords

apoptosis development gene therapy genes transcription

Editors and affiliations

  • Nagy A. Habib
    • 1
  1. 1.Imperial College School of MedicineHammersmith HospitalLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/b113267
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-46191-0
  • Online ISBN 978-0-306-46817-9
  • Series Print ISSN 0065-2598
  • About this book
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