The Biology and Pathology of Innate Immunity Mechanisms

  • Yona Keisari
  • Itzhak Ofek

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 479)

Table of contents

  1. Front Matter
    Pages i-x
  2. Pattern Recognition, Receptors and Collectins in Innate Immunity

    1. Itzhak Ofek, Erika Crouch, Yona Keisari
      Pages 27-36
    2. Moshe Kalina, Hanna Blau, Shoshana Riklis, Vered Hoffman
      Pages 37-48
    3. Kevan L. Hartshorn, Mitchell R. White, R. Alan B. Ezekowitz, Kedamath Sastry, Erika Crouch
      Pages 49-59
    4. Michal Shani-Sekler, Sarit Lifshitz, Iris Hillel, Ron Dagan, Nili Grossman, Gideon Fleminger et al.
      Pages 61-71
  3. Host Cells and Cytokinesin Innate Immunity

  4. Antimicrobial Peptides

    1. Margherita Zanetti, Renato Gennaro, Marco Scocchi, Barbara Skerlavaj
      Pages 203-218
    2. Haim Tsubery, Itzhak Ofek, Sofia Cohen, Mati Fridkin
      Pages 219-222
  5. Innate Immunity in the Compromised Host

  6. Innate Immunity Components in Cancer

    1. O. Itzhaki, E. Skutelsky, T. Kaptzan, A. Siegal, M. Michowitz, J. Sinai et al.
      Pages 251-262
    2. T. Kaptzan, E. Skutelsky, M. Michowitz, A. Siegal, O. Itzhaki, S. Hoenig et al.
      Pages 263-275
    3. Ron N. Apte, Tatyana Dvorkin, Xiaoping Song, Eyal Fima, Yakov Krelin, Alon Yulevitch et al.
      Pages 277-288
    4. Pages 289-322
  7. Back Matter
    Pages 323-328

About this book


In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.


antigen antimicrobial antimicrobial peptides bacteria bacterial infection infection infections

Editors and affiliations

  • Yona Keisari
    • 1
  • Itzhak Ofek
    • 1
  1. 1.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-46409-6
  • Online ISBN 978-0-306-46831-5
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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