© 2005

Molecular Autoimmunity

  • Moncef Zouali


  • Dr. Moncef Zouali is an internationally known autoimmune researcher of a very high standing and visibility in the field of autoimmune diseases

  • The chapter authors are also the best in their field


Table of contents

  1. Front Matter
    Pages i-xxvii
  2. Innate Immunity in Autoimmune Diseases

    1. Ziya Kaya, Noel R. Rose
      Pages 1-15
    2. Paul N. Moynagh
      Pages 17-25
    3. Terry W. Du Clos, Carolyn Mold
      Pages 27-41
    4. Shabbir Hussain, Dalam Ly, Melany Wagner, Terry L. Delovitch
      Pages 43-53
  3. Genetics of Autoimmune Diseases

    1. Marta E. Alarcón-Riquelme
      Pages 55-67
    2. Yan Yang, Erwin K. Chung, Karl Lhotta, Yee Ling Wu, Gloria C. Higgins, Robert M. Rennebohm et al.
      Pages 85-99
  4. Triggers of the Autoimmune Attack

    1. Christian Veldman, Michael Hertl
      Pages 127-139
    2. Liesbeth Spaenij-Dekking, Frits Koning
      Pages 141-150
  5. Targets of the Autoimmune Attack

    1. Paola Migliorini, Consuelo Anzilotti, Laura Caponi, Federico Pratesi
      Pages 165-180
    2. S. Ansar Ahmed, Ebru Karpuzoglu-Sahin
      Pages 181-196
    3. Monika Bradl, Hans Lassmann
      Pages 209-225
  6. Immune Receptor Signaling Pathways

About this book


2004 marks the 100th anniversary of the first description of the autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder, by Julius Donath and Karl Landsteiner. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies.

Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.


Antigen autoimmune disease autoimmunity interferon protein transplantation

Editors and affiliations

  • Moncef Zouali
    • 1
  1. 1.Institut National de Santé et de Recherche Médicale (INSERM)ParisFrance

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