Retinal Degenerative Diseases and Experimental Therapy

  • Joe G. Hollyfield
  • Robert E. Anderson
  • Matthew M. LaVail

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Specific Gene Defects Cause Photoreceptor Degeneration

    1. Front Matter
      Pages 1-1
    2. David S. Williams, Xinran Liu, Gordon Vansant, Brian Ondek
      Pages 15-26
    3. Christian P. Hamel, Françoise Marlhens, Jean-Michel Griffoin, Corinne Bareil, Mireille Claustres, Bernard Arnaud
      Pages 27-33
    4. Breandán N. Kennedy, John C. Saari, John W. Crabb
      Pages 43-53
    5. Hans-Jürgen Fülle, Rima Khankan
      Pages 55-65
    6. David G. Birch, Ruey-Bing Yang, Susan W. Robinson, David L. Garbers
      Pages 67-80
    7. Matthias C. Grieshaber, Eugen Boltshauser, Günter Niemeyer
      Pages 95-104
    8. Jeanne Frederick, Nataliia Krasnoperova, Kirstin Hoffmann, Wolfgang Baehr, Janis Lem, Klaus Rüther
      Pages 105-115
    9. Dusanka Deretic, Sonia Schmerl, Paul A. Hargrave, Anatol Arendt, J. Hugh McDowell
      Pages 117-128
    10. Yuko Wada, Mitsuru Nakazawa, Toshiaki Abe, Makoto Tamai
      Pages 151-156
    11. Yoshihiro Hotta, Keiko Fujiki, Mutsuko Hayakawa, Misako Takeda, Nao Kohno, Atsushi Kanai et al.
      Pages 157-163
    12. Jean-Michel Rozet, Sylvie Gerber, Imad Ghazi, Isabelle Perrault, Eric Souied, Dominique Ducroq et al.
      Pages 165-174
    13. I. B. Griesinger, P. A. Sieving, R. Ayyagari
      Pages 175-181
    14. Shreeta Acharya, Ignacio R. Rodriguez, Joe G. Hollyfield
      Pages 183-187
    15. Alessandro Iannaccone, Benedetto Falsini, Neena Haider, Giuseppe Del Porto, Edwin M. Stone, Val C. Sheffield
      Pages 189-199
    16. A. Martínez-Mir, E. Paloma, S. Balcells, L. Vilageliu, S. J. Pittler, R. Gonzàlez-Duarte
      Pages 201-213
    17. Makoto Tamai, Hiroshi Kunikata, Masahiro Tsunoda
      Pages 215-222
    18. Radha Ayyagari, Laura E. Kakuk, Yumiko Toda, Caraline L. Coats, Eve L. Bingham, Janet J. Szczesny et al.
      Pages 223-234
    19. Tong Cheng, Muna I. Naash
      Pages 235-249
    20. E. M. Vingolo, R. Allingham, C. Palitto, L. Scipioni, L. Iacobelli
      Pages 251-258
    21. E. M. Vingolo, C. Palitto, L. Scipioni, L. Iacobelli
      Pages 259-263
  3. Gene Therapy for Photoreceptor Rescue

    1. Front Matter
      Pages 265-265
    2. Lynn C. Shaw, Patrick O. Whalen, Kimberly A. Drenser, Wei-Ming Yan, William W. Hauswirth, Alfred S. Lewin
      Pages 267-275
    3. John G. Flannery, Alfred S. Lewin, Kimberly A. Drenser, Shimpei Nishikawa, Douglas Yasumura, Matthew M. LaVail et al.
      Pages 277-291
    4. Vijay Sarthy
      Pages 293-302
  4. The Involvement of Light in Retinal Degeneration

    1. Front Matter
      Pages 303-303
    2. G. B. Arden, J. E. Wolf, J. Collier, C. Wolff, M. Rosenberg
      Pages 305-316
    3. Matthew M. LaVail, Naveen N. Kumar, Gregg M. Gorrin, Douglas Yasumura, Michael T. Matthes
      Pages 317-324
    4. De-Mao Chen, Guangjun Dong, William S. Stark
      Pages 325-335
    5. Donald M. Allen, Chris Pipes, Kristi Deramus, Ted E. Hallows
      Pages 337-350
    6. Theodore P. Williams, Barbara N. Baker, Janice Dodge
      Pages 351-360
    7. T. Matsukawa, Z. -Y. Zhou, K. Sugawara, M. Devadas, K. Sugitani, S. Kato
      Pages 361-369
  5. Animal Models with Photoreceptor Degeneration

    1. Front Matter
      Pages 371-371
    2. Hiroyuki Nambu, Kenshi Yuge, Motomaro Nakajima, Kanji Takahashi, Hirohiko Miki, Masanobu Uyama et al.
      Pages 373-381
    3. P. E. Rakoczy, W. Y. Shen, K. Spilsbury, M. Yu, M. Lai, C. J. Barry et al.
      Pages 383-392
    4. Arman Tehrani, Thomas H. Wheeler-Schilling, Eberhart Zrenner, Elke Guenther
      Pages 393-405
    5. S. Weiss, T. Herrmann, A. Stett, E. Zrenner, H. Haemmerle
      Pages 407-416
  6. Molecular and Cell Biological Studies

    1. Front Matter
      Pages 417-417
    2. Vikas Kancherla, Wojciech Kedzierski, Gabriel H. Travis, Monica M. Jablonski
      Pages 419-429
    3. Cheryl M. Craft, Xuemei Zhu, Jaji Murage, Xiankui Li
      Pages 431-442
    4. Joe G. Hollyfield, Mary E. Rayborn, Shreeta Acharya
      Pages 443-448
  7. Retinal Prosthesis as a Replacement for Photoreceptors

    1. Front Matter
      Pages 461-461
    2. Joseph F. Rizzo, John Loewenstein, John Wyatt
      Pages 463-469

About this book


To create a forum for scientists and clinicians interested in degenerative retinal diseases, we began in 1984 to organize a biennial symposium on Retinal Degeneration as a satellite meeting of the International Congress of Eye Research. The timing and varying location of these meetings provides an important assembly for investigators from throughout the world to convene for presentation of their new findings on the causes and potential therapies for degenerative retinal disorders. The VIII International Symposium on Retinal Degeneration was held from July 28-25, 1998, at the Hotel Vier Jahreszeiten in Schluchsee, a small town in the Black Forest of southwestern Germany. Most of the participants in this meeting contributed to this volume, and we are appreciative of the efforts of each author in making this publication possible. The research presented at the meeting, and described in this proceedings volume, reflects a strong emphasis on the molecular genetic approach to understa- ing these disorders. Several of the papers provide important new insights into the mechanism of photoreceptor degeneration and cell death. A number of the studies are targeted at retarding or reversing the degeneration process. Included for the first time are presentations from all the principal laboratories involved in the field of visual prostheses-implant (chip) technology-in which investigations are targeted at restoring vision in eyes that have lost photoreceptor cells. A variety of diagnostic, clinical, histopathological, and physiological assessments of retinal degeneration in patients are also included.


cells gene therapy genes genetics molecular biology transplantation

Editors and affiliations

  • Joe G. Hollyfield
    • 1
  • Robert E. Anderson
    • 2
  • Matthew M. LaVail
    • 3
  1. 1.Cole Eye InstituteThe Cleveland Clinic FoundationCleveland
  2. 2.Dean A. McGee Eye InstituteUniversity of Oklahoma Health Sciences CenterOklahoma City
  3. 3.Beckman Vision CenterUniversity of California, San FranciscoSan Francisco

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